Results 121 to 130 of about 5,797,712 (321)

Fluctuations in Gene Regulatory Networks as Gaussian Colored Noise

, 2009
The study of fluctuations in gene regulatory networks is extended to the case of Gaussian colored noise. Firstly, the solution of the corresponding Langevin equation with colored noise is expressed in terms of an Ito integral.
Alon U., Arkin A., Coddington E., Jinn-Wen Wu, Karen G. Petrosyan, Ming-Chang Huang, Ptashne M., Toral R., van Kampen N. G., Yu-Pin Luo   +9 more
core   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

A pH-Sensitive Peptide-Containing Lasso Molecular Switch

Molecules, 2013
The synthesis of a peptide-containing lasso molecular switch by a self-entanglement strategy is described. The interlocked [1] rotaxane molecular machine consists of a benzometaphenylene[25]crown-8 (BMP25C8) macrocycle surrounding a molecular axle.
Karine Fournel-Marotte, Caroline Clavel, Frédéric Coutrot   +2 more
doaj   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Caspases: A Molecular Switch Node in the Crosstalk between Autophagy and Apoptosis

International Journal on Biological Sciences, 2014
Autophagy and apoptosis are two important catabolic processes contributing to the maintenance of cellular and tissue homeostasis. Autophagy controls the turnover of protein aggregates and damaged organelles within cells, while apoptosis is the principal ...
Haijian Wu, Xiaoru Che, Q. Zheng, An Wu, Kun Pan, Anwen Shao, Qun Wu, Jianmin Zhang, Yuan Hong   +8 more
semanticscholar   +1 more source

pH-Sensitive Multiliposomal Containers for Encapsulation and Rapid Release of Bioactive Substances

Molecules
A new method of the design of stimuli-sensitive multiliposomal containers for encapsulation and controlled drug release is described. Despite quite a wide choice of pH-sensitive containers, there is still a considerable challenge to synthesize those that
Anna A. Efimova, Tatyana A. Abramova, Igor V. Yatsenko, Alexey V. Kazantsev, Denis V. Pozdyshev, Nikolay V. Lukashev, Vladimir I. Muronets, Alexander A. Yaroslavov   +7 more
doaj   +1 more source

Transitions Induced by the Discreteness of Molecules in a Small Autocatalytic System

, 2001
Autocatalytic reaction system with a small number of molecules is studied numerically by stochastic particle simulations. A novel state due to fluctuation and discreteness in molecular numbers is found, characterized as extinction of molecule species ...
B. Alberts, B. Hess, B. Hess, C. Furusawa, C. Furusawa, D. A. Kessler, F. Rieke, G. Nicolis, H. H. McAdams, K. Kaneko, K. Kaneko, K. Matsumoto, K. Wiesenfeld, Kunihiko Kaneko, M. Delbruck, M. Eigen, N. G. van Kampen, P. Stange, P. Stange, P. Stange, W. Horsthemke, Yuichi Togashi   +21 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Structural Bases for the Fitness Cost of the Antibiotic-Resistance and Lethal Mutations at Position 1408 of 16S rRNA

Molecules, 2019
To understand a structural basis for the fitness cost of the A1408G antibiotic-resistance mutation in the ribosomal A-site RNA, we have determined crystal structures of its A1408C and A1408U lethal mutants, and made comparison with previously solved ...
Jiro Kondo, Mai Koganei
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source