Results 211 to 220 of about 5,797,712 (321)

Network Localization of Fatigue in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Fatigue is among the most common symptoms and one of the main factors determining the quality of life in multiple sclerosis (MS). However, the neurobiological mechanisms underlying fatigue are not fully understood. Here we studied lesion locations and their connections in individuals with MS, aiming to identify brain networks ...
Olli Likitalo, Jaakko Kungshamn, Albert Bellmunt‐Gil, Silvia Tommasin, Abhineet Ojha, Matias Viitala, Juho Aaltonen, Jyrki Lötjönen, Juha Koikkalainen, Pauli Ylikotila, Patrizia Pantano, Merja Soilu‐Hänninen, Juho Joutsa   +12 more
wiley   +1 more source

Generalizable Molecular Switch Designs for <i>In Vivo</i> Continuous Biosensing. [PDF]

Acc Chem Res
Saunders J, Thompson IAP, Soh HT.
europepmc   +1 more source

Inhibition of Classical and Alternative Complement Pathway by Ravulizumab and Eculizumab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the feasibility of classical (CH50) and alternative (AH50) complement pathway activity as potential biomarkers for treatment guidance and monitoring during therapy with ravulizumab in patients with generalized myasthenia gravis (gMG) and compare these to therapeutic drug monitoring under eculizumab.
Lea Gerischer, Frauke Stascheit, Maximilian Mönch, Paolo Doksani, Carla Dusemund, Meret Herdick, Philipp Mergenthaler, Maike Stein, Amani Suboh, Jutta Schröder‐Braunstein, Guido Wabnitz, Jan D. Lünemann, Sophie Lehnerer, Sarah Hoffmann, Andreas Meisel   +14 more
wiley   +1 more source

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism.

Immunity, 2013
James M. Murphy, P. Czabotar, Joanne M. Hildebrand, I. Lucet, Jian‐guo Zhang, Silvia Álvarez-Díaz, Rowena S. Lewis, N. Lalaoui, D. Metcalf, A. Webb, Samuel N. Young, L. Varghese, G. Tannahill, Esme C. Hatchell, I. Majewski, T. Okamoto, R. Dobson, D. Hilton, J. Babon, N. Nicola, A. Strasser, J. Silke, W. Alexander   +22 more
semanticscholar   +1 more source

Exosome-mediated miRNA delivery: a molecular switch for reshaping neuropathic pain therapy. [PDF]

Front Mol Neurosci
Wei Z, Guo C, Zhou H, Wu Y, Zhou X, Chen J, Li F.   +6 more
europepmc   +1 more source

Lys417 acts as a molecular switch that regulates the conformation of SARS-CoV-2 spike protein. [PDF]

Elife, 2023
Geng Q, Wan Y, Hsueh FC, Shang J, Ye G, Bu F, Herbst M, Wilkens R, Liu B, Li F.   +9 more
europepmc   +1 more source

Olink Proteomics Analysis Reveals Heterogeneous Responses to FcRn Blockade in Anti‐AChR Antibody‐Positive Myasthenia Gravis: FGF‐19 as a Novel Biomarker

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to systematically observe the clinical manifestations, immune cell subsets, and dynamic changes in serological indicators in patients with myasthenia gravis (MG) before and after efgartigimod (EFG) treatment. Methods We analyzed the baseline data, laboratory parameters, and lymphocyte subset proportions in MG ...
Tiancheng Luo, Deyou Peng, Zhouao Zhang, Mingjin Yang, Xinyan Guo, Tianyu Ma, Xiaoyu Huang, Mingming Xu, Linlin Fu, Yong Zhang   +9 more
wiley   +1 more source

Nuclear paxillin functions as a molecular switch for alternative splicing in neurons during a critical period of brain development. [PDF]

EMBO J
Chu CH, Pan GZ, Tsai CY, Yu CA, Lin HN, Chiang HL, Chen C, Chen LC, Pham XT, Lin CL, Cheng PL.   +10 more
europepmc   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

An Electrochromic Tristable Molecular Switch.

Journal of the American Chemical Society, 2015
Junling Sun, Yilei Wu, Yuping Wang, Zhichang Liu, Chuyang Cheng, K. Hartlieb, M. Wasielewski, J. Stoddart   +7 more
semanticscholar   +1 more source