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Hepatocellular carcinoma: molecular mechanism, targeted therapy, and biomarkers.
Cancer metastasis reviews, 2023Yu Wang, B. Deng
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Combinations of Molecular-Targeted Therapies
2007With our awareness of the complexity of cancer cell biology has come the appreciation that strategies aiming at simultaneous blockade of multiple molecular pathways will be critical to further therapeutic success. Given the availability of numerous targeted agents for clinical testing, there are now considerable interest and optimism for combination ...
Janet Dancey, Helen X. Chen
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Molecular Targeted Therapies for HCC
2009The years of fundamental cancer biology research is now starting to pay clinical dividends, with the identification of key enzymatic steps in the growth control and angiogenesis pathways, resulting in specific chemical inhibitors and antibodies to several of the involved kinases. This has led to a whole new family of novel, non-chemotherapy agents that
Susan Kralian, Brian I. Carr
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Molecular targeting therapy for pancreatic cancer
Cancer Chemotherapy and Pharmacology, 2004Pancreatic carcinogenesis is driven by multiple genetic and epigenetic changes. The epidermal growth factor receptor (EGFR) and its downstream signaling pathways, Ras-Raf-MEK-ERK axis, play important roles in pancreatic cancer development. The phosphoinositol 3 kinase (PI3 K)/Akt and the nuclear factor kappaB (NF-kappaB) pathways control both ...
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Molecular targeted therapy for hepatocellular carcinoma
Journal of Gastroenterology, 2009A majority of patients with HCC present with advanced disease and are not candidates for liver transplantation, surgical resection, or regional therapy. Systemic cytotoxic chemotherapy agents are minimally effective, can have significant toxicity, and have not been shown to improve patient survival. Hepatocellular carcinomas are inherently chemotherapy-
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Molecular targeted therapy: Treating cancer with specificity
European Journal of Pharmacology, 2018Yeuan Ting Lee, Y. Tan, C. Oon
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Treatment of lung adenocarcinoma by molecular-targeted therapy and immunotherapy
Surgery today (Print), 2017M. Saito +4 more
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Advances of Molecular Targeted Therapy in Gastric Cancer
Journal of Gastrointestinal Cancer, 2016B. Cetin, O. Gumusay, M. Cengiz, A. Ozet
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