Results 181 to 190 of about 2,067,232 (315)

Molecule Shapes

open access: yes, 2014
O recurso simula o modelo em 3D de algumas moléculas, suas possíveis ligações, geometria molecular e eletrônica, além de ressaltar o efeito da repulsão eletrônica entre os pares de elétrons não ligantes na geometriaEnsino Médio::QuímicaEducação Superior::
Chamberlain, Julia   +4 more
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Catching the active form of a protein by single molecule methodologies

open access: yes, 2007
The structural disorder of intrinsically unstructured proteins is the outcome of a complex ensemble of conformers driven by a rugged energy landscape.
SAMORI', BRUNO
core  

A simple Schiff base compound as mitigator for the destruction of C-steel in HCl aqueous solutions: practical and theoretical studies. [PDF]

open access: yesSci Rep
Saleh MGA   +7 more
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Mechanistic Study of Diketopiperazine Formation during Solid-Phase Peptide Synthesis of Tirzepatide

open access: yesACS Omega, 2022
Jingyao Wang   +11 more
doaj   +1 more source

Orthogonal nanopores cross-validation for multiplex single-molecule profiling. [PDF]

open access: yesChem Sci
Zhang LL   +7 more
europepmc   +1 more source

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