Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
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AET5: A transcriptome-guided molecular generation framework with contrastive self-supervised learning. [PDF]
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Identification of a key water molecule involved in the macrophage migration inhibitory factor-catalyzed tautomerization of para-hydroxyphenylpyruvate using neutron crystallography. [PDF]
Protein SciSchröder GC +7 more
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Is AI Capable of Real-World Drug Discovery? [PDF]
J Chem Inf ModelMcGaughey G.
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Correction for Closson et al., Context-dependent variability of HIF heterodimers influences interactions with macromolecular and small molecule partners. [PDF]
Proc Natl Acad Sci U S Aeuropepmc +1 more source
Structural and single-molecule insights into the core human mitochondrial DNA replisome. [PDF]
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A Graph-Based Machine Learning Framework to Assign Empirical Interaction Parameters for Novel Molecules. [PDF]
J Comput ChemFu Y, Stroet M, O'Mara ML.
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