Results 271 to 280 of about 3,841,010 (347)

Infra-red investigations of molecular structure. Part II.—The molecule of nitric oxide

, 1929
C. P. Snow, F. I. G. RAWLINS, Eric Keightley Rideal   +2 more
openalex   +1 more source

Scaffold Hopping with Generative Reinforcement Learning. [PDF]

J Chem Inf Model
Rossen L, Sirockin F, Schneider N, Grisoni F.   +3 more
europepmc   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Single-molecule sequencing maps replication dynamics across the fission yeast genome, including centromeres

Díez-Santos I, Thiyagarajan S, Rogers AM, Watson AT, Carr AM, Nieduszynski CA.   +5 more
europepmc   +1 more source

Single-Molecule Phosphorescence and Intersystem Crossing in a Coupled Exciton Plasmon System. [PDF]

ACS Nano
Grewal A, Imada H, Miwa K, Imai-Imada M, Kimura K, Jaculbia R, Kuhnke K, Kern K, Kim Y.   +8 more
europepmc   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Single-Molecule Protein Interactions and Unfolding Revealed by Plasmon-Enhanced Fluorescence. [PDF]

Anal Chem
Teeuwen RWH, Russo M, Merkx M, Zijlstra P.   +3 more
europepmc   +1 more source

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

Molecular Oncology, EarlyView.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza, Robert Carlsson, Coralie Gamper, Gayatri Chitale, Johan Bengzon, Gesine Paul   +5 more
wiley   +1 more source

Regulatory T Cells Control Vascular Adhesion Molecule Expression in Skin Under Inflammatory and Homeostatic Conditions. [PDF]

Microcirculation
Norman MU, Lim B, Jenkins L, Hall P, Snelgrove SL, Hickey MJ.   +5 more
europepmc   +1 more source