Results 271 to 280 of about 5,323,640 (377)

FDA-approved small-molecule kinase inhibitors.

TIPS - Trends in Pharmacological Sciences, 2015
Peng Wu, T. Nielsen, M. Clausen
semanticscholar   +1 more source

The structure and dynamics of water molecule networks underlie catalytic efficiency in a glycoside exo-hydrolase. [PDF]

Commun Biol
Luang S, Fernández-Luengo X, Streltsov VA, Maréchal JD, Masgrau L, Hrmova M.   +5 more
europepmc   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Approximate Calculation of Normal Frequencies of Similar Molecules.

, 1955
Ichirô Nakagawa
openalex   +2 more sources

Rotational Energy Transfer in Diatomic Molecules [PDF]

, 1954
R. Brout
openalex   +1 more source

Paving the way to single-molecule protein sequencing

Nature Nanotechnology, 2018
Laura Restrepo-Pérez, Chirlmin Joo, C. Dekker   +2 more
semanticscholar   +1 more source

Characterizing the Membrane Assembly of ASGPR Related to Mediated Endocytosis Using TriGalNAc-Probe-Based Super-Resolution Imaging. [PDF]

JACS Au
Chen J, Wang J, Sui B, Jiang P, Wang X, Wang H, Liang F.   +6 more
europepmc   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Melatonin: an ancient molecule that makes oxygen metabolically tolerable

Journal of Pineal Research, 2015
L. Manchester, A. Coto-Montes, J. Boga, Lars Peter H. Andersen, Zhou Zhou, A. Galano, J. Vriend, D. Tan, R. Reiter   +8 more
semanticscholar   +1 more source