Results 311 to 320 of about 5,474,193 (390)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Application of chemical similarity and bioisosteres to find allosteric inhibitors of type 2 lipid kinase γ. [PDF]

Sci Rep
Andola P, Pagag J, Naresh GKRS, Guruprasad L.   +3 more
europepmc   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Atomically precise construction of uniform single-molecule junctions for molecular electronics. [PDF]

Nat Commun
Li M, Yin B, Wang B, Hu W, Cheng J, Gao C, Li Z, Xu Y, Yang C, Xie X, Guo J, Zhao C, Wang J, Gao X, Zhang Y, Zhou J, Yang Z, Migliore A, Jia C, Guo X.   +19 more
europepmc   +1 more source

Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma

Molecular Oncology, EarlyView.
Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf, Daniel Ehinger, Hans Brunnström, Mats Jönsson, Frida Rosengren, Marija Kotevska, Anna Karlsson, Mattias Aine, Christian Frezza, Maria Planck, Elsa Arbajian   +10 more
wiley   +1 more source

Single-molecule graphene quantum dots: enhancement of optical properties and promotion of photodynamic efficacy based on precise control of the electronic structure. [PDF]

Chem Sci
Chen J, Li B, Liu D, Yin S, Qi J, Lu Z, Liu Y, Gao T.   +7 more
europepmc   +1 more source

Two-Photon Absorption and Dynamics of Excited States in Bromochalcone Derivatives. [PDF]

J Phys Chem A
Marucci NB, Valverde JVP, Campos GO, Ducas ESA, Gonçalves PJ, De Boni L, Mendonça CR.   +6 more
europepmc   +1 more source

Engineering nanopore in monolayer WS₂ for single-molecule imaging on the atomic-scale flat 2D surfaces. [PDF]

Sci Adv
He H, Zhao M, Xu H, Chang L, Jiang Y, Bai Y, Wang C, Nong H, Ma L, Gan L, Zhang T, Kang F, Liu B, Lei Y.   +13 more
europepmc   +1 more source

Molecular Mechanism of ATP Hydrolysis Catalyzed by p97: A QM/MM Study. [PDF]

J Chem Theory Comput
Szántó JK, Hulm A, Ochsenfeld C.
europepmc   +1 more source

Regulating enol-keto tautomerism at the single-molecule level with a confined optical field. [PDF]

Chem Sci
Adijiang A, Ge Y, Feng H, Yan Y, Zuo X, Wang H, Zhao X, Tan M, Zhang S, Xu X, Chen L, Wang C, Li Z, Xiang D.   +13 more
europepmc   +1 more source