Liver Endothelia Orchestrate MASH‐Associated Macrophage Zonation Through FSTL1‐ITGA4 Axis
Advanced Science, EarlyView.Liver inflammation in MASH fundamentally hinges on the newly defined Kit/STAT2/FSTL1/ITGA4 axis. Declining endothelial Kit collapses normal hepatic zonation, driving an aberrant FSTL1 gradient that recruits pathogenic macrophages. Strikingly, targeting FSTL1‐ITGA4 with anti‐VLA4 restores spatial immune homeostasis and halts disease progression ...
Lin Sun +10 more
wiley +1 more source
Mollification formulas and implicit smoothing. [PDF]
, 2003 Research Report UCDMS 2003/19This paper develops some mollification formulas involving convolutions between popular radial basis function (RBF) basic functions ϕ, and suitable mollifiers k.
Beatson, R. K., Bui, H. -Q.
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MULTISCALE ANALYSIS BY MEANS OF DISCRETE MOLLIFICATION FOR ECG NOISE REDUCTION
, 2009 Multiscale analysis and computation is a rapidly evolving area of research that have had a fundamental impact on computational science and applied mathematics and have influenced the way we view the relation between mathematics and science.
PULGARÍN-GIRALDO, JUAN +2 more
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Transposable Element–Driven PIEZO Mutation Enhances Locust Flight in Plateau Hypoxia
Advanced Science, EarlyView.Why transposable elements (TEs) persisted or expanded in genomes remains a mystery. Using integrated analysis of TE macro‐ and microevolution in locusts, our results showed that thousands of TE insertions promoted widespread adaptive variation. Subfamilies of candidate adaptive TEs amplified and reshaped species‐level genomic architecture.
Xuanzhao Li +8 more
wiley +1 more source
Numerical solution of generalized IHCP by discrete mollification [PDF]
, 1996 A numerical space marching algorithm based on discrete mollification and automatic iterative filtering by Generalized Cross Validation is applied to the solution of a generalized one-dimensional inverse heat conduction problem.
Murio, D.A., Mejía, C.E.
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A Panel of Circulating Exosomal sncRNAs Associated With Lung Cancer Risk up to 10 Years in Advance
Advanced Science, EarlyView.Lung cancer is often diagnosed too late, and current screening overlooks many people at risk. In a long‐term study of smokers, a panel of small non‐coding RNAs carried in blood exosomes signals elevated lung cancer risk up to ten years before diagnosis, pointing toward a blood‐based tool for earlier risk detection.
Zhuokun Feng +12 more
wiley +1 more source
Combined mollification—future temperatures procedure for solution of inverse heat conduction problem [PDF]
, 1988 The inverse heat conduction problem involves the calculation of surface heat flux and/or temperature histories from transient, measured temperatures inside solids.
Murio, Diego A., Paloschi, Jorge R.
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Unveiling the Taxonomic Diversity and Unprecedented Biosynthetic Treasure of the Phylum Myxococcota
Advanced Science, EarlyView.Natural products remain vital sources of therapeutics, and the phylum Myxococcota constitutes an especially rich reservoir for them. Based on decades of microbiological efforts, we present 154 new Myxococcota genomes and revise taxonomy quadrupling the number of families and genera.
Amay Ajaykumar Agrawal +25 more
wiley +1 more source
Identification of transmissivity coefficients by mollification techniques. Part I: One-dimensional elliptic and parabolic problems [PDF]
, 1993 We discuss the numerical identification of the transmissivity coefficient in the one-dimensional linear and nonlinear elliptic and parabolic partial differential equations.
Murio, Diego A., Hinestroza, Doris
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Groundwater Rise Sustains the World's Largest Alpine Water System Under Global Warming
Advanced Science, EarlyView.Shallow groundwater depth (SGWD) across the non‐permafrost plains of the Qinghai–Xizang Plateau decreased at averagely 0.02 m year−1, adding 31.44 Gt of freshwater storage from 2000 to 2020 and sustaining ∼53 500 km2 of alpine ecosystems. A vadose‐zone capacity of 426.6 Gt reveals these aquifers as promising reservoirs, highlighting groundwater's ...
Jianqing Du +15 more
wiley +1 more source