Results 221 to 230 of about 792,784 (309)

Lactate‐H3K18la‐RPL11 Axis Drives Gemcitabine Resistance in Pancreatic Cancer by Integrating Protein Synthesis and DNA Damage Repair

open access: yesAdvanced Science, EarlyView.
A lactate‐H3K18la epigenetic axis upregulates RPL11 to drive gemcitabine resistance in pancreatic cancer. RPL11 orchestrates chemoresistance through a dual, compartmentalized role: enhancing cytoplasmic protein synthesis via EEF1A1 stabilization and promoting nuclear DNA damage repair by co‐activating PARP14, thus ensuring robust cell survival ...
Lijun Zhao   +10 more
wiley   +1 more source

Ionically Counter‐Programmable Phase‐Separation of Superstable Star‐Biopolyamide Coacervates for Electrothermally‐Responsive Pseudosolid Smart Windows

open access: yesAdvanced Science, EarlyView.
We develop bio‐based, star‐branched polyamides from itaconic acid and cadaverine with tunable lower critical solution temperature (LCST) transitions for dynamic solar modulation. Specific metal ion coordination with pyrrolidone moieties drives precise phase transitions via calcium‐induced salting‐in and sodium‐induced salting‐out mechanisms. Formulated
Jie Liu   +6 more
wiley   +1 more source

Advancing Biotherapeutic Treatment of Ulcerative Colitis Using Lipid Mesophases: Formulation Design and Preclinical Validation

open access: yesAdvanced Science, EarlyView.
Lipid mesophases provide a versatile platform for colon‐targeted delivery of biotherapeutics, protecting them from degradation while enhancing mucoadhesion and enabling localized, controlled release to the inflamed mucosa after oral or rectal administration. In a DSS‐induced colitis model, this strategy reduced disease activity, inflammatory biomarkers,
Rafaela Gazzi   +13 more
wiley   +1 more source

Microstructure Evolution in Dry‑Coated Sulfidic All‐Solid‐State Battery Cathodes: Investigating Core–Shell Particle Morphology

open access: yesAdvanced Science, EarlyView.
Mixing method directly governs interface engineering and electrode morphology during the dry coating of all‐solid‐state battery cathodes. While high‐shear batch mixing yields poor electrode quality and lacks core–shell‐like features, continuous extruder mixing enables strong binder fibrillation and a core–shell‐like coating between the active material ...
Michael Wolf   +7 more
wiley   +1 more source

Multistage nucleation pathway in LiF molten salt mirrors the crystal-melt interface structure. [PDF]

open access: yesProc Natl Acad Sci U S A
Fan Z   +4 more
europepmc   +1 more source

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