Results 51 to 60 of about 8,200 (237)

Minerals and insulin dependent diabetes in children: A review article

SVU - International Journal of Medical Sciences
Background: The human body contains trace levels of minerals and other micronutrients. Particularly advantageous for physiologic processes, a wide range of biochemical processes, stabilizing proteins and enzymes, and serving as cofactors for different ...
Khaled Abdalla Abdelbaseer, Zeinab Mohammad Mohey El-Deen, Mohammed H. Hassan , Fatma El-Zahraa Mostafa Abo EL-Magd*, Eman Ahmed Abd-Elmawgood   +4 more
doaj   +1 more source

Molybdenum cofactor biology, evolution and deficiency

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2021
The molybdenum cofactor (Moco) represents an ancient metal‑sulfur cofactor, which participates as catalyst in carbon, nitrogen and sulfur cycles, both on individual and global scale. Given the diversity of biological processes dependent on Moco and their evolutionary age, Moco is traced back to the last universal common ancestor (LUCA), while Moco ...
Simon J, Mayr, Ralf-R, Mendel, Guenter, Schwarz   +2 more
openaire   +2 more sources

Engineering Compact Base Editors by AlphaFold‐Guided Mutation Scan and Escherichia coli‐Based Tri‐Selection

Advanced Science, EarlyView.
A miniaturized deaminase SsdAtox was scanned with AlphaFold to identify DNA binding pocket hot spots. Site‐saturation mutagenesis at gatekeeper residue K31 yielded ten‐fold activity enhancement. Trinity Screen, an E. coli‐based three‐in‐one platform selecting for high activity and reduced double‐strand breaks, enabled combinatorial evolution at DNA ...
Ryeo Gang Son, Goeun Kim, Jungjoon K. Lee   +2 more
wiley   +1 more source

Biology of the molybdenum cofactor [PDF]

Journal of Experimental Botany, 2007
The transition element molybdenum (Mo) is an essential micronutrient for plants where it is needed as a catalytically active metal during enzyme catalysis. Four plant enzymes depend on molybdenum: nitrate reductase, sulphite oxidase, xanthine dehydrogenase, and aldehyde oxidase.
openaire   +2 more sources

Negative Cooperativity in the Nitrogenase Fe Protein Electron Delivery Cycle [PDF]

, 2016
Nitrogenase catalyzes the ATP-dependent reduction of dinitrogen (N2) to two ammonia (NH3) molecules through the participation of its two protein components, the MoFe and Fe proteins.
Antony, Edwin, Danyal, Karamatullah, Dean, Dennis R., Duval, Simon, Hoffman, Brian M., Horitani, Masaki, Lukoyanov, Dmitriy, Marts, Amy R., Page, Taylor R., Raugei, Simone, Seefeldt, Lance C., Shaw, Sudipta   +11 more
core   +2 more sources

The Transcription Factor FgSge1 Harnesses the SAGA Complex to Activate Mycotoxin Biosynthesis and Fungal Virulence

Advanced Science, EarlyView.
This study reveals the molecular mechanism by which the transcription factor FgSge1 regulates mycotoxin biosynthesis and virulence in Fusarium graminearum. FgSge1 binds to the TAARGTTT cis‐element, enabling self‐activation. It recruits the SAGA complex, promotes histone acetylation, and facilitates jet‐like chromatin remodeling, thereby activating ...
Yueqi Zhang, Jingrui Wang, Qiaowan Chen, Chen Jiao, Yun Chen, Zhongshou Wu, Zhonghua Ma   +6 more
wiley   +1 more source

Plasma, Urinary, Erythrocyte, and Platelet Concentrations of Manganese and Molybdenum in Football Players: Differences between Sexes and during the Season

Applied Sciences
Physical activity induces modifications in the concentrations of trace mineral elements. However, studies exploring sex-related differences in manganese (Mn) and molybdenum (Mo) levels among athletes are scarce.
Victor Toro-Román, Fco Javier Grijota, Marcos Maynar-Mariño, Amalia Campos, Almudena Martínez-Sánchez, María C. Robles-Gil   +5 more
doaj   +1 more source

The production and detoxification of a potent cytotoxin, nitric oxide, by pathogenic enteric bacteria [PDF]

, 2011
The nitrogen cycle is based on several redox reactions that are mainly accomplished by prokaryotic organisms, some archaea and a few eukaryotes, which use these reactions for assimilatory, dissimilatory or respiratory purposes.
Anke Arkenberg, Bleakley, Bodenmiller, Brunelli, Chakravortty, Cherayil, Constantinidou, Crawford, Cruz-Ramos, David J. Richardson, Filenko, Gardner, Gary Rowley, Gilberthorpe, Gilchrist, Husain, Justino, Mastroeni, Miller, Mills, Overton, Prior, Pullan, Ramotar, Richardson, Rodionov, Sebastian Runkel, Shiloh, Smith, Spiro, Todorovic, Tripathi, van Wonderen, Vine, Vine, Wang, Wink   +36 more
core   +1 more source

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source

Influence of the molybdenum cofactor biosynthesis on anaerobic respiration, biofilm formation and motility in Burkholderia thailandensis [PDF]

, 2014
types: Journal Article; Research Support, Non-U.S. Gov'tCopyright © 2013 Institut Pasteur. Published by Elsevier Masson SAS.Elsevier. NOTICE: This is the author’s version of a work accepted for publication by Elsevier.
Andreae, Clio A., Butler, Clive S, Titball, Richard W.   +2 more
core   +1 more source