Results 81 to 90 of about 8,200 (237)
Vaspin identified as a DNA‐binding serpin with functional consequences for protease inhibition
The FEBS Journal, EarlyView.Vaspin is a serpin that is expressed in skin, adipose tissue, and liver. It binds to single‐ and double‐stranded DNA with high affinity. This binding is unaffected by mutation of the known heparin‐binding site, accelerates the inhibition of the inflammatory protease KLK7, and may contribute to vaspin's nuclear localization.
Kevin Möhlis +9 more
wiley +1 more source
The pterin molybdenum cofactors.
Journal of Biological Chemistry, 1992 crassa, demonstrated that the inactive apoprotein of nitrate reductase in extracts of the mutant could be reconstituted by the addition of denatured preparations of purified molybdoenzymes from animal, fungal, or bacterial origin. This crucial finding showed that mol- ybdoenzymes contain a dissociable entity fitting the description of a cofactor and ...
K V, Rajagopalan, J L, Johnson
openaire +2 more sources
Strategies for stable anaerobic digestion of vegetable waste [PDF]
, 2012 International trade and the market demand for pre-prepared agricultural produce is not only increasing the total quantity of waste agricultural biomass but also centralising its availability, making it potentially useful for energy production.
Banks, Charles J. +2 more
core +1 more source
The FEBS Journal, EarlyView.NOTCH signalling is indispensable for tissue homeostasis and, consequently, corruption of its normal function promotes numerous diseases, including cancer. However, the development of targeted therapies has been hampered by inefficacy and overt toxicity. Here, we show that NOTCH receptor dimerization is necessary for receptor transactivation, which has
Xinxin Liu +9 more
wiley +1 more source
Microbial transformation of elements: the case of arsenic and selenium [PDF]
, 2010 Microbial activity is responsible for the transformation of at least one third of the elements in the periodic table. These transformations are the result of assimilatory, dissimilatory, or detoxification processes and form the cornerstones of many ...
J. Stolz, P. Basu, R. Oremland
core +2 more sources
The FEBS Journal, EarlyView.Quinolones are valuable scaffolds for drug discovery but are rare in nature. Here, we show that two fungal enzymes, AthePKS and FerePKS, can generate 2‐quinolones and two additional heteroaromatic scaffolds. Using AthePKS, we designed an artificial enzymatic cascade towards an antimicrobial quinolone from a simple precursor and implemented it in E ...
Nika Sokolova +5 more
wiley +1 more source
High molybdenum availability for evolution in a Mesoproterozoic lacustrine environment [PDF]
, 2015 Peer ...
Andrews, Steven +4 more
core +1 more source
The FEBS Journal, EarlyView.Cystine (Cys2) deprivation in pancreatic cancer cells induces oxidative stress that destabilizes cytosolic iron–sulfur cluster (ISC) proteins, triggering an iron‐regulatory protein (IRP)‐mediated iron‐starvation response (ISR). This leads to increased iron uptake (via TFRC), an expanded labile iron pool, and ferroptosis.
Mingjun Tan +8 more
wiley +1 more source
Reversible interconversion of CO2 and formate by a molybdenum-containing formate dehydrogenase. [PDF]
, 2014 CO2 and formate are rapidly, selectively, and efficiently interconverted by tungsten-containing formate dehydrogenases that surpass current synthetic catalysts.
Bassegoda, Arnau +4 more
core +2 more sources
The FEBS Journal, EarlyView.Characterization of anhydromevalonate phosphate decarboxylase, the UbiD‐family decarboxylase involved in the archaeal mevalonate pathway, was conducted. The enzyme is responsible for the biosynthesis of isoprenoids, such as archaeal membrane lipids, respiratory quinones, and dolichols.
Rino Ishikawa +9 more
wiley +1 more source