Results 91 to 100 of about 615,062 (247)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Mechanical Demands at the Ankle Joint During Saut de Chat and Temps levé Jumps in Classically Trained Ballet Dancers

Open Access Journal of Sports Medicine, 2019
Sarah K Perry, Harsh H Buddhadev, Lorraine R Brilla, David N Suprak Department of Health and Human Development, Western Washington University, Bellingham, WA, USACorrespondence: Harsh H BuddhadevDepartment of Health and Human Development, Western ...
Perry SK, Buddhadev HH, Brilla LR, Suprak DN   +3 more
doaj  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

A Comparative In Vitro Analysis of Attachment and Enhanced Structural Features for Molar Distalization in Clear Aligner Therapy

Applied Sciences
This study evaluated the effects of different clear aligner (CA) designs on forces and moments during maxillary second molar distalization. Four designs were tested: attachment only (group 1), neither attachment nor enhanced structure (group 2), a ...
Youn-Kyung Choi, Min-Jeong Jee, Sung-Hun Kim, Seong-Sik Kim, Soo-Byung Park, Yong-Il Kim   +5 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Fırçasız Doğru Akım Makinalarında Optimal Hall Sensör Yerinin Bulunması Çalışmaları

Düzce Üniversitesi Bilim ve Teknoloji Dergisi, 2016
Bu çalışmada bipolar sürücülü hall sensörlü fırçasız doğru akım motoru (FSDAM)’nun sensörlerinin, optimal çalışma aralığı deneysel olarak araştırılmıştır.
Kemal Hasanusta, N.füsun Oyman Serteller   +1 more
doaj  

The New Strange Generalized Rayleigh Family: Characteristics and Applications to COVID-19 Data

Iraqi Journal for Computer Science and Mathematics
In this paper, we introduce a novel family of continuous distributions known as the Odd Generalized Rayleigh-G Family. Within this family, we present a special sub-model known as the odd Generalized Rayleigh Inverse Weibull (OGRIW) distribution.
Alaa A. Khalaf, Mundher A. khaleel
doaj   +1 more source