Results 151 to 160 of about 1,224,771 (316)
Prezentizmus a prítomný moment (Presentism and the present moment )
, 2017 The paper examines the relation between presentism and the experience of the present moment. Some presentists believe that our experience of the present moment is in correspondence with the presentistic theory of the present moment. This link between our
Juraj Odorčák
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
The Moment of Racial Sight A History
The Moment of Racial Sight overturns the most familiar form of racial analysis in contemporary culture: the idea that race is constructed, that it operates by attaching visible marks of difference to arbitrary meanings and associations. Searching for the
Tucker, Irene.
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Inferring Network Characteristics via Moment-Based Estimators
, 2001 In this work we develop simple inference models based on finite capacity single server queues for estimating the buffer size and the intensity of cross traffic at the bottleneck link of a path between two hosts.
Don Towsley +3 more
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
, 2016 “Amacımız Fark Yaratacak Makine Mühendisleri Yetiştirmek” Gelişen teknolojiye ayak uydurabilen, teknik bilgi ve becerilere sahip fark yaratacak lider makine mühendisleri yetiştirmek üzere yola çıktıklarını belirten MEF Üniversitesi Makine Mühendisliği ...
Delale, Can Fuat
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