Results 81 to 90 of about 615,062 (247)
Physical Treatments, 2016 Purpose: The negative heel rocker shoes help reduce the plantar pressure in patients with diabetes, but their effects on the other lower limb joints are unknown.
Keyvan Sharifmoradi +2 more
doaj
Applied SciencesThis study evaluates the biomechanical efficacy of clear aligners in closing anterior maxillary diastemas using enhanced force systems. While clear aligners offer esthetic and functional benefits, their predictability in controlling bodily movement and ...
Min-Jeong Jee +5 more
doaj +1 more source
Exploring health navigating design: momentary contentment in a cancer context
International Journal of Qualitative Studies on Health & Well-Being, 2017 Purpose: The technocratic and medicalized model of healthcare is rarely optimal for patients. By connecting two different studies we explore the possibilities of increasing quality of life in cancer care.
Ulrika Sandén +3 more
doaj +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Research on the new process of separating hollow work-piece by eccentric torsion cutting for stamping [PDF]
FME TransactionsThis work aims to conduct theoretical and experimental studies on the energy and force parameters of the separation process, as well as the geometric accuracy of the separated tubular workpiece using the "eccentric twisting" method.
Karnaukh Sergii G. +2 more
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Applied SciencesThis study aimed to optimize space closure efficiency by comparing the forces and moments exerted by different designs of clear aligners (CAs) during the movement of maxillary canines into the premolar extraction space.
Youn-Kyung Choi +4 more
doaj +1 more source