Results 101 to 110 of about 1,058,580 (309)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Dynamic Panel Data Model and Moment Generating Function [PDF]
This paper proposes new sets of moment restrictions for consistently estimating the dynamic panel data model. These sets are derived from solving the moment generating functions of the error term for the dynamic panel data model and have the relevancy ...
Yoshitsugu Kitazawa
core
Consistent estimation in an implicit quadratic measurement error model
, 2004 An adjusted least squares estimator is derived that yields a consistent estimate of the parameters of an implicit quadratic measurement error model. In addition, a consistent estimator for the measurement error noise variance is proposed.
Er Kukush +5 more
core +1 more source
Efficient estimation of the density and distribution functions of Weibull-Burr XII distribution
Alexandria Engineering JournalThis study takes into account the efficient estimation of the probability density function (PDF) of the Weibull-Burr XII distribution and the cumulative distribution function (CDF), which allows for greater flexibility than many other generalized ...
Amulya Kumar Mahto +4 more
doaj +1 more source
Jackknife Bias Reduction in the Presence of a Near-Unit Root
Econometrics, 2018 This paper considers the specification and performance of jackknife estimators of the autoregressive coefficient in a model with a near-unit root.
Marcus J. Chambers, Maria Kyriacou
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
The Generalized Method of Moments in the Bayesian Framework and a Model of Moment Selection Criterion [PDF]
While the classical framework has a rich set of limited information procedures such as GMM and other related methods, the situation is not so in the Bayesian framework.
Jae-Young Kim
core
Consistent Moment Selection Procedures for Generalized Method of Moments Estimation [PDF]
Econometrica, 1999 Summary: This paper considers a generalized method of moments (GMM) estimation problem in which one has a vector of moment conditions, some of which are correct and some incorrect. The paper introduces several procedures for consistently selecting the correct moment conditions.
openaire +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source