Results 211 to 220 of about 1,518,720 (358)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Multiscale Machine Learning Prediction of Infrared Spectra of Solvated Molecules. [PDF]

J Chem Theory Comput
Mazzeo P, Cupellini L, Mennucci B.
europepmc   +1 more source

Convergence of Binomial, Poisson, Negative-Binomial, and Gamma to Normal Distribution: Moment Generating Functions Technique

, 2016
Subhash C. Bagui, K. L. Mehra
openalex   +1 more source

Extension of Ostrowki type inequality via moment generating function

, 2020

openalex   +1 more source

Estimation of non-Gaussian noise parameters in the wavelet domain using the moment-generating function [PDF]

, 2012
Jan Švihlík
openalex   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Fluctuation Relations Associated to an Arbitrary Bijection in Path Space. [PDF]

Math Phys Anal Geom
Chétrite R, Marcantoni S.
europepmc   +1 more source

Applications of multiple orthogonal polynomials with hypergeometric moment generating functions [PDF]

Thomas Wolfs
openalex   +1 more source

Approximating unbounded functions with linear operators generated by moment sequences [PDF]

, 1970
S. Eisenberg, B. Wood
openalex   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source