Results 41 to 50 of about 1,865,478 (288)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Rapid Moment Magnitude Estimation Using Strong Motion Derived Static Displacements [PDF]
, 2015 The static surface deformation can be recovered from strong motion records. Compared to satellite-based measurements such as GPS or InSAR, the advantage of strong motion records is that they have the potential to provide real-time coseismic static ...
Murjaya, Jaya +3 more
core +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Coda-derived source properties estimated using local earthquakes in the Sea of Marmara, Türkiye [PDF]
Solid EarthAccurate estimates of the moment magnitude of earthquakes that physically measure the earthquake source energy are crucial for improving our understanding of seismic hazard in regions prone to tectonic activity. To address this demand, a method involving
B. Özkan +3 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Source parameters and seismic moment-magnitude scaling for northwestern Turkey
, 2007 The source parameters of 523 aftershocks (0.5 12 Hz) fall-off of the acceleration source spectra by computing the K parameter. The seismic moments obtained range between 1.05 x 10(14) and 2.41 x 10(17) N m, whereas the Brune stress drops are between 0 ...
Durukal E +4 more
core +2 more sources
Magnitude analysis of aftershocks of the Mw 9.3 Sumatra-Andaman Earthquake recorded at the temporary PSU Seismic Station in Phang nga, Thailand [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2008 After the Mw 9.3 Sumatra-Andaman Earthquake on 26 December 2004, a temporary broadband seismic station was set up at the Khao Chang Telecommunication Station in Phang nga Province, Southern Thailand, in order to monitor aftershocks in an area bounded by ...
Helmut Düerrast +2 more
doaj
Rapid estimation of tsunami earthquake magnitudes at local distance
Earth, Planets and Space, 2021 A tsunami earthquake is an earthquake event that generates abnormally high tsunami waves considering the amplitude of the seismic waves. These abnormally high waves relative to the seismic wave amplitude are related to the longer rupture duration of such
Akio Katsumata +2 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source