Results 71 to 80 of about 1,865,478 (288)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Relationships of Seismic Source Parameters and Magnitude for Mw ≥ 7.0 Earthquakes

open access: yesApplied Sciences
Literature-based compilation indicates that there have been 165 earthquakes with moment magnitude Mw ≥ 7.0 in the period 1980–2024 for which identifiable source-parameter estimates are available.
Kuan Shi, Qingxu Yu, Ye Bai, Chen Xia
doaj   +1 more source

Analysis of strong-motion data of the 1990 Eastern Sicily earthquake

open access: yesAnnals of Geophysics, 1995
The strong motion accelerograms recorded during the 1990 Eastern Sicily earthquake have been analyzed to investigate source and attenuation parameters. Peak ground motions (peak acceleration, velocity and displacement) overestimate the values predicted ...
E. Boschi   +4 more
doaj   +1 more source

Assessing infrequent large earthquakes using geomorphology and geodesy in the Malawi Rift [PDF]

open access: yes, 2015
In regions with large, mature fault systems, a characteristic earthquake model may be more appropriate for modelling earthquake occurrence than extrapolating from a short history of small, instrumentally observed earthquakes using the Gutenberg–Richter ...
Biggs, Juliet   +9 more
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

Estimation of seismic moments from local magnitudes and coda durations for the Cairo earthquake aftershocks recorded at Kottamyia (KEG) Broadband station

open access: yesAnnals of Geophysics, 2003
The spectral analysis of fifty-five KEG VBB records from the October 12, 1992 Cairo earthquake source region was performed to obtain the seismic moment.
M. F. Abdelwahed   +3 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

Determination of radiated energy and energy-moment ratio for the 2025 Dingri, Xizang M6.8 earthquakeKey points

open access: yesEarthquake Science
Radiated seismic energy is a quantitative characteristic of an earthquake that depends not only on the initial and final stresses, but also on the rupture history, and reflects the dynamic characteristics of the source.
Yixiao Zhang   +3 more
doaj   +1 more source

Seismic Moment Tensor Solutions from GeoNet Data to Provide a Moment Magnitude Scale for New Zealand

open access: yes, 2008
The aim of this project is to enable accurate earthquake magnitudes (moment magnitude, MW) to be calculated routinely and in near real-time for New Zealand earthquakes.
Robertson, Elizabeth de Joux   +1 more
core   +1 more source

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