FEBS Open Bio, EarlyView.CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama +7 more
wiley +1 more source
Innovation under pressure: bold ideas for a changing malaria landscape. [PDF]
BMC Glob Public HealthEpstein A, Tangena JA.
europepmc +1 more source
A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms
FEBS Open Bio, EarlyView.We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley +1 more source
Can Asymmetrical Mechanical Loading Be Accurately Inferred From the Analysis of Skeletal Material? [PDF]
Am J Biol AnthropolProfico A, Jeffery N, Karakostis FA.
europepmc +1 more source
HSP70 governs permeability and mechanotransduction in primary human endothelial cells
FEBS Open Bio, EarlyView.HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez +5 more
wiley +1 more source
Accuracy Analysis of SINS/CNS Integrated Attitude Determination Based on Simplified Spatio-Temporal Model. [PDF]
Sensors (Basel)Ruan C, Li H, Li C, Chen S, Hong Z.
europepmc +1 more source
The consequences of dismantling community-led HIV programming in Kenya: a call to action from the HEKA programme research partnership in Kenya. [PDF]
BMJ Glob HealthWalimbwa Wambaya J +19 more
europepmc +1 more source
Beyond encampments: an evidence-based path to solving Canada's homelessness crisis. [PDF]
Lancet Reg Health AmKaramouzian M, Hwang SW, Werb D.
europepmc +1 more source
CO Visibilities, Image Cubes, Moment Maps and Radial profiles (ARKS IV)
Sorcha Mac Manamon
openalex +1 more source