Results 71 to 80 of about 84,435 (298)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Moment maps and diffeomorphisms [PDF]
Some times ago in a very nice paper, \textit{M. F. Atiyah} and \textit{R. Bott} [Philos. Trans. R. Soc. Lond., Ser. A 308, 523-615 (1983; Zbl 0509.14014)], proved that the curvature of a connection on a bundle over a surface can be viewed as the momentum corresponding to the action of the gauge group.
openaire +2 more sources
Quantum moment map and obstructions to the existence of closed Fedosov star products
peer reviewedIt is shown that the normalized trace of Fedosov star product for quantum moment map depends only on the path component in the cohomology class of the symplectic form and the cohomology class of the closed formal 2-form required to define ...
LA FUENTE-GRAVY, Laurent, Futaki, Akito
core +1 more source
In this paper, we show that the notion of moment map for the Hamiltonian action of a Lie group on a symplectic manifold is a special case of a much more general notion. In particular, we show that one can associate a moment map to a family of Hamiltonian symplectomorphisms, and we prove that its image is characterized, as in the classical case, by a ...
Guillemin, Victor, Sternberg, Shlomo
openaire +2 more sources
Diversity and complexity in neural organoids
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Morse theory of the moment map for representations of quivers [PDF]
The results of this paper concern the Morse theory of the norm-square of the moment map on the space of representations of a quiver. We show that the gradient flow of this function converges, and that the Morse stratification induced by the gradient flow
Megumi Harada +3 more
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Integrated correlators at strong coupling in an orbifold of N $$ \mathcal{N} $$ = 4 SYM
We consider the 4d N $$ \mathcal{N} $$ = 2 superconformal quiver gauge theory obtained by a ℤ2 orbifold of N $$ \mathcal{N} $$ = 4 super Yang-Mills (SYM). By exploiting supersymmetric localization, we study the integrated correlator of two Coulomb branch
Alessandro Pini, Paolo Vallarino
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source

