Results 31 to 40 of about 16,101 (266)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Machine learning-based prediction of moment redistribution in statically indeterminate reinforced concrete flexural members

Discover Civil Engineering
The transfer of moments between critical and non-critical regions is a key behavior in statically indeterminate reinforced concrete (RC) structures, enhancing the utilization of less critical sections and improving the overall ductility and safety of the
Fatma Attia, Hamed Salem
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Ductility of continuous RC beams strengthened with partially bonded near-surface mounted CFRP bars

Journal of King Saud University: Engineering Sciences
Carbon fiber–reinforced polymer (CFRP) rods have been implemented for repair and strengthening work in several applications for reinforced concrete (RC) elements. The linear brittle behavior of these composite materials can be an excessive limitation for
Mahmoud A. Abdelraouf, Ayman H. Khalil, Ahmed F. Maree, Amr M. Ibrahim   +3 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

REDISTRIBUSI MOMEN PADA BALOK KOMPOSIT MENERUS DENGAN MEMPERHATIKAN PENGARUH MOMEN INERSIA NEGATIF

Civil Engineering Dimension, 2001
Elastic analysis of continuos composite beams, assumes constant second moment of area constant over the length of the beam, giving hogging moment at internal supports higher than sagging moment at midspan.
Hasan Santoso, Handoko Sugiharto
doaj  

Quantifying moment redistribution in FRP-strengthened RC beams [PDF]

Proceedings of the Institution of Civil Engineers - Structures and Buildings, 2016
Consideration of moment redistribution (MR) in the design of continuous reinforced concrete (RC) beams results in an efficient and economical design. Adding fibre-reinforced polymer (FRP) materials to reinforced structures to enhance flexural capacity leads to a reduction in ductility, such that design standards severely limit use of the MR in their ...
Tajaddini, A, Ibell, T, Darby, A, Evernden, M, Silva, P   +4 more
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source