Results 91 to 100 of about 2,024,233 (364)
FEBS Letters, EarlyView.Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez +3 more
wiley +1 more source
A New Extension of the Generalized Half Logistic Distribution with Applications to Real Data
Entropy, 2019 In this paper, we introduced a new three-parameter probability model called Poisson generalized half logistic (PoiGHL). The new model possesses an increasing, decreasing, unimodal and bathtub failure rates depending on the parameters. The relationship of
Mustapha Muhammad, Lixia Liu
doaj +1 more source
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
Predicting moment-to-moment attentional state
NeuroImage, 2014 Although fluctuations in sustained attention are ubiquitous, most psychological experiments treat them as noise, averaging performance over many trials. The current study uses multi-voxel pattern analysis (MVPA) to decode whether, on each trial of a cognitive task, participants are in an optimal or suboptimal attentional state.
Monica D. Rosenberg +3 more
openaire +4 more sources
Maximum-Entropy Method for Evaluating the Slope Stability of Earth Dams
Entropy, 2012 The slope stability is a very important problem in geotechnical engineering. This paper presents an approach for slope reliability analysis based on the maximum-entropy method.
Shuai Wang, Wei Wang, Chuanqi Li
doaj +1 more source
Moment generating functions of record values from a class of doubly truncated distributions
Journal of Taibah University for Science, 2020 In this paper, we consider a class of doubly truncated distributions. Based on this class, recurrence relation for moment generating functions of record values is derived.
Abd EL-Baset A. Ahmad +2 more
doaj +1 more source
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Parameter Estimation for the Log-Logistic Distribution Based on Order Statistics
Revstat Statistical Journal, 2018 In this paper, we discuss the moments and product moments of the order statistics in a sample of size n drawn from the log-logistic distribution. We provide more compact forms for the mean, variance and covariance of order statistics.
Mohammad Ahsanullah , Ayman Alzaatreh
doaj +1 more source
On the truncated operator trigonometric moment problem [PDF]
arXiv, 2015 In this paper we study the truncated operator trigonometric moment problem. All solutions of the moment problem are described by a Nevanlinna-type parameterization. In the case of moments acting in a separable Hilbert space, the matrices of the operator coefficients in the Nevanlinna-type formula are calculated by the prescribed moments. Conditions for
arxiv
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source