Results 41 to 50 of about 464,024 (288)
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Eternity Descending into Time: Badiou and the Cinematic Temporality of Love
Film-PhilosophyThis article brings Alain Badiou’s philosophy of love and truth into the consideration of the cinematic real. It argues that love has been overlooked in the discourse of the cinematic real and that love should be recuperated in and for cinema so that a ...
Lu Zeng
doaj +1 more source
Electronics Letters, 2019 Alzheimer's disease (AD) is a progressive neurodegenerative disorder that causes brain regions to undergo structural changes. Shape descriptors are useful in reflecting the morphological alterations of brain structures in AD conditions compared to volume
R. Dadsena +3 more
doaj +1 more source
Multi-Channel Stochastic Variational Inference for the Joint Analysis of Heterogeneous Biomedical Data in Alzheimer's Disease [PDF]
, 2018 The joint analysis of biomedical data in Alzheimer's Disease (AD) is important for better clinical diagnosis and to understand the relationship between biomarkers.
A Klami +10 more
core +3 more sources
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Retorica politică și metafora istoriei: entelehia poetică a lui Hugo von Hofmannsthal în vremea sa [PDF]
Polis: Revista de Stiinte Politice, 2022 The common good is realized in the encounter of those moments that reveal the passage from the historical identification of truth to redemption as an archetypal recognition by man of God the Creator, letting that special explosion give life to the ...
Gianfranco LONGO
doaj
, 2018 When Wittgenstein was young, he wrote a small book intended to solve all of philosophy’s problems with language, called Tractatus Logico-Philosophicus (1922). As an intellectual piece, the Tractatus is a strange beast, written by a student with the voice
Marin, Lavinia
core
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
MARKETING APPROACHES TO CUSTOMER EXPERIENCE MEASUREMENT AND EVALUATION
Вестник университета, 2017 The article shows the variety of existing marketing methods to measure and evaluate the consumer experience. The necessity of creation of a comprehensive Customer Experience Management System on the basis of empirical data in order to create a platform ...
A. Serzhantov, M. Orlova
doaj