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The Antigluconeogenic Activity of Cucurbitacins from Momordica charantia

Planta Medica, 2015
Five new cucurbitacins, kuguacins II-VI (1-5), along with five known analogues (6-10), were obtained from the fruit of Momordica charantia. Structures of the new compounds were elucidated as 5β,19-epoxycucurbit-23-en-7-on-3β,25-diol (1), 5β,19-epoxycucurbit-7,23-dion-3β,25-diol (2), 5β,19-epoxycucurbit-6-en-19,23-dion-3β,25-diol (3), 5β,19-epoxy-23,24 ...
Minghua Qiu   +2 more
exaly   +3 more sources

Antimutagens from Momordica charantia

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1990
The antimutagenic principle of the green fruits of Momordica charantia was shown by the micronucleus test to be an intractable mixture of novel acylglucosylsterols. The antimutagens were extracted from the green fruits with ethanol and isolated from the bioactive petroleum ether and carbon tetrachloride extracts by repeated and sequential flash column ...
A P, Guevara   +3 more
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Momordica charantia L. Cucurbitaceae

2020
It is a climbing, nearly or quite smooth, annual vine that is widely grown in Asia (especially Indian subcontinent), Africa, and in central Europe. Hindu physicians in India used the whole plant combined with cinnamon, long pepper, rice and the oil of Hydnocarpus wightiana as an external application in scabies and other skin diseases. Fruits and leaves
Narel Y. Paniagua-Zambrana   +2 more
  +4 more sources

Extra-pancreatic effects of Momordica charantia in rats

Journal of Ethnopharmacology, 1986
The extra pancreatic effects of the oral hypoglycaemic plant Momordica charantia have been investigated in rats. It was found that the fruit juice of this plant caused an increased glucose uptake by tissues in vitro without concomitant increase of tissue respiration.
J, Welihinda, E H, Karunanayake
openaire   +2 more sources

Hypoglycaemic Effect ofMomordica charantiaExtracts

Planta Medica, 1990
The hypoglycaemic effect of orally administered extracts of fruits of cultivated Momordica charantia (karela) was examined in normal and streptozotocin diabetic mice. In normal mice, an aqueous extract (A) lowered the glycaemic response to both oral and intraperitoneal glucose, without altering the insulin response.
C, Day   +3 more
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Insulin-like molecules in Momordica charantia seeds

Journal of Ethnopharmacology, 1986
Decorticated Momordica charantia seeds were extracted and processed by a method which was developed originally for the purification of insect and annelid insulins. Essentially, the method entailed HCl--ethanol extraction, neutralization with NH4OH, gel filtration on Sephadex G-50, ion exchange chromatography on CM Sepharose CL-6B and desalting on ...
T B, Ng, C M, Wong, W W, Li, H W, Yeung
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Pharmacodynamic interaction of Momordica charantia with rosiglitazone in rats

Chemico-Biological Interactions, 2009
The present study was undertaken to determine the interaction of rosiglitazone, a PPAR-gamma agonist with methanolic extract of Momordica charantia L (MC), an herbal drug used widely as an antidiabetic agent. The pharmacodynamic interaction was evaluated in oral glucose tolerance test, streptozotocin (STZ) induced diabetes in adult rats and STZ induced
Susan Nancy, Nivitabishekam   +2 more
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Cucurbitane triterpenoids from Momordica charantia

Magnetic Resonance in Chemistry, 2007
AbstractThree new cucurbitane‐type triterpenoid saponins, 23‐O‐β‐D‐allopyranosyl‐5β,19‐epoxycucurbita‐6,24‐diene‐3β,22(S),23(S)‐triol‐3‐O‐β‐D‐glucopyranoside (1), 23‐O‐β‐D‐allopyranosyl‐5β,19‐epoxycucurbita‐6,24‐diene‐3β,22(S),23(S)‐triol‐3‐O‐β‐D‐allopyranoside (2), and 23‐O‐β‐D‐allopyranosyl‐5β,19‐epoxycucurbita‐6,24‐diene‐3β,19(R), 22(S),23(S ...
Qing-Yan, Li   +4 more
openaire   +2 more sources

Effect of Momordica charantia on key hepatic enzymes

Journal of Ethnopharmacology, 1994
The effect of Momordica charantia on certain key hepatic enzymes was investigated using male Sprague-Dawley rats as the animal model. Fruit juice and seed extract of Momordica charantia were administered orally at a daily dose of 1 ml/100 g body weight for 30 days under light ether anaesthesia while the control group received equivalent amounts of ...
K H, Tennekoon   +4 more
openaire   +2 more sources

Pazopanib/Momordica charantia

Reactions Weekly, 2022
openaire   +1 more source

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