Results 121 to 130 of about 24,609 (262)

How can biological databases support the new UN mechanism for benefit-sharing from digital sequence information? [PDF]

Sci Data
Raposo DS, Faggionato D, Ebert B, Orozco P, Cochrane G, Bao Y, Arita M, Muñoz-García M, Freitag J, Hirsch T, Cook CE, Vos R, Reimer L, Ratnasingham S, Rouard M, Brinkley S, Lange M, Scholz U, Weise S, Usadel B, Finn RD, Park CH, Haas AS, Castle D, O'Cathail C, Scholz AH.   +25 more
europepmc   +1 more source

Cost‐utility analysis of nusinersen–risdiplam switch in patients with spinal muscular atrophy in Croatia: A discrete event simulation model

British Journal of Clinical Pharmacology, EarlyView.
Introduction In recent years, the treatment of spinal muscular atrophy (SMA), a rare disease, has significantly progressed, improving patients' survival and overall quality of life. However, current SMA treatments are expensive, and some (nusinersen) are very inconvenient for patients.
Andrej Belančić, Ivana Stević, Elvira Meni Maria Gkrinia, Dinko Vitezić, Slobodan Janković   +4 more
wiley   +1 more source

Neural Representations and Functional Connections Underlie Subjective Positive Affect. [PDF]

J Neurosci
Savalia T, Huang XA, Martin S, Ramakrishnan SD, Cohen AO.   +4 more
europepmc   +1 more source

How the HTAR will contribute to a value‐based decision‐making for medicinal products across the EU

British Journal of Clinical Pharmacology, EarlyView.
The European Union Health Technology Regulation 2021/2282 (HTAR) introduces joint assessment of health technologies (including medicinal products and medical devices) across EU Member States. It was signed into law in 2021 and came into full force in January 2025.
Roisin Adams, Michal Stanak
wiley   +1 more source

Temporal Dynamics of Reward Dysfunction in Psychiatric Disorders: Memory-Derived Value, Incentive Salience, Hedonic Impact, and Value Updating. [PDF]

Biol Psychiatry Glob Open Sci
Zou F, Yang X, Liu C, Li K, Zhang M.
europepmc   +1 more source

Beyond the label: Rethinking off‐label drug use in paediatrics. Towards a scientifically grounded and safer future for paediatric pharmacotherapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden, Miriam G. Mooij, Matthijs de Hoog, Saskia N. de Wildt   +3 more
wiley   +1 more source

Agentic systems in computational pathology: architectures, evidence, and translational challenges. [PDF]

J Transl Med
Lu X, Li Q, Gao Y, Dong W, Lyu M, Ma S, Li J, Wu Y, Cai L, Zhang T, Lyu S, Liu Z, Liu H, Luo S.   +13 more
europepmc   +1 more source

Zuranolone: A case study in (regulatory) rush to judgement?

British Journal of Clinical Pharmacology, EarlyView.
Abstract Sage, in collaboration with Biogen, submitted a new drug approval for zuranolone for postpartum depression (PPD) and major depressive disorder (MDD) in December 2022. In August 2023, the US Food and Drug Administration granted approval for PPD but denied approval for MDD.
Lisa Cosgrove, Milutin Kostic, Barbara Mintzes, Gianna D'Ambrozio, Allen Shaughnessy   +4 more
wiley   +1 more source

Habit Formation to Enhance Implementation of Evidence-based Practice. [PDF]

Adm Policy Ment Health
Patel-Syed Z, Scott K, Helseth S, Becker S.   +3 more
europepmc   +1 more source

Safety concerns reported by coroners following fentanyl patch fatalities in England, Wales and Northern Ireland between 1997 and 2024

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim To identify safety concerns reported by coroners following fentanyl patch‐related deaths in England, Wales and Northern Ireland, and determine differences in coronial reporting. Methods A systematic case series linking the National Programme on Substance Use Mortality (NPSUM) and the Preventable Deaths Tracker (PDT) (https ...
Eman Mshari, Caroline S. Copeland, Georgia C. Richards   +2 more
wiley   +1 more source