Results 191 to 200 of about 53,257 (299)

Cysteine Peptidases in Antitumor Immunity: Unraveling Antigen‐Presenting Cell Regulation and Therapeutic Potential

open access: yesiMetaMed, EarlyView.
This review systematically summarizes the central role of cysteine peptidases in modulating antigen‐presenting cell (APC) function and antitumor immune responses, highlighting their critical significance in overcoming tumor immune evasion. Current research has established that cysteine peptidase subtypes, including cathepsins B, S, L, and X, exert ...
Yimao Wu   +7 more
wiley   +1 more source

Ancient Mongolian aurochs and cattle genomes reveal population shifts associated with the expansion of herding. [PDF]

open access: yesiScience
Brunson K   +22 more
europepmc   +1 more source

A Cross‐Species Hormone Knowledge Base With Multi‐Dimensional Data Integration and Intelligent Query Assistance

open access: yesiMetaMed, EarlyView.
AHormoneDB is a no‐code platform that combines DOID‐standardized hormone–disease associations, regulatory prediction, and retrieval‐augmented generation‐based querying. In acromegaly, it nominated PTPN1 as a previously underappreciated candidate, demonstrating its capacity to accelerate mechanistic discovery.
Xingxing Huang   +6 more
wiley   +1 more source

Gut microbiome seasonality is associated with dietary plasticity and coexistence in three sympatric Pamir ungulates

open access: yesiMetaOmics, EarlyView.
This graphical abstract outlines a multi‐omics framework investigating the seasonal dietary composition and gut microbial communities of three coexisting ungulate species inhabiting the extreme high‐altitude Pamir Plateau (Ovis ammon polii, Capra sibirica, and Pseudois nayaur). By integrating dietary DNA metabarcoding, 16S rRNA gene sequencing, shotgun
Dilala Tuoliu   +8 more
wiley   +1 more source

Impact of Geography on Institutions in Agricultural and Nomadic Societies

open access: yesInternational Studies of Economics, EarlyView.
ABSTRACT How geography affects the choice of institutions is studied in a theoretical model. In this model, nations are located around a circle. Rulers compete through choosing tax rates, the level of military spending, and the degree of formality of institutions. Geographic condition is captured by population density.
Haiwen Zhou
wiley   +1 more source

A Tale of Two Transitions: Mobility Dynamics in China and Russia After Central Planning

open access: yesJournal of Applied Econometrics, EarlyView.
ABSTRACT This paper examines intergenerational mobility in China and Russia during their transitions from central planning to market systems. We consider mobility as movement, measured as changes in status between parents and children. We provide estimates of two key mobility measures: overall mobility, which captures total intergenerational movement ...
Kristina Butaeva   +3 more
wiley   +1 more source

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