Results 101 to 110 of about 2,636,072 (304)
As a novel adipose‐derived neurotrophic factor, Follistatin‐like 1 is endocytosed by sympathetic neurons primarily via tropomyosin‐related kinase B. This process promotes sympathetic innervation in adipose tissue and norepinephrine release, leading to white adipose tissue browning, enhanced thermogenesis, and anti‐obesity effects in mice.
Xiao‐Wei Jia +13 more
wiley +1 more source
An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu +7 more
wiley +1 more source
Twenty-four hour central ambulatory blood pressure, arterial stiffness, and nocturnal fluctuations
Arterial stiffness and blood pressure (BP) increase with aging and are independently related to increased cardiovascular disease (CVD) risk; yet the relationship remains misunderstood.
Jones, Olivia E.
core
Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley +1 more source
BackgroundMood monitoring and ambulatory assessment offer improvements in measuring mood and behavior for mental health research and clinical practice.
Laurence Astill Wright +3 more
doaj +1 more source
The incidence of side effects and their relation with anesthetic techniques after ambulatory surgery
The aim of this study was to evaluate the incidence of side effects and their relation with anesthetic techniques in patient undergoing ambulatory surgery.
core +1 more source
ABSTRACT Background Frailty predicts outcomes after colorectal cancer surgery, but postoperative changes remain unclear. We previously reported improvement in FRAIL Scale‐based frail/pre‐frail status 1 year after curative minimally invasive surgery (MIS).
Hajime Ushigome +9 more
wiley +1 more source
Objective To explore patients’ experiences and perspectives on using a direct-to-consumer smartwatch with single-lead electrocardiography (1L-ECG) for ambulatory rhythm diagnostics in primary care.Design Qualitative study using semi-structured interviews
Eric Wierda +6 more
doaj +1 more source
ABSTRACT Background Work‐related injuries may increase risk for opioid‐related harms. Yet there remains a gap in our understanding of trends in opioid‐related harms over time among injured workers. We estimated trends in hospital encounters for opioid‐related harms among injured workers in Ontario, Canada from 2006 to 2022.
Jeavana Sritharan +4 more
wiley +1 more source

