Results 151 to 160 of about 4,280,969 (314)

To monitor, or not to monitor, that is the question

Indian Pacing and Electrophysiology Journal
Rakesh Agarwal, Rajiv Mahajan
openaire   +3 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Environmental monitoring and characterization /

, 2004
Environmental Monitoring and Characterization is an integrated, hands-on resource for monitoring all aspects of the environment. Sample collection methods and relevant physical, chemical and biological processes necessary to characterize the environment ...
Artiola, Janick F., Pepper, Ian L., Brusseau, Mark L.   +2 more
core  

Pregnancy Monitoring [PDF]

Computational and Mathematical Methods in Medicine, 2014
Massimo Mischi, Brynjar Karlsson, Maria G. Signorini, M. Ungureanu, Catherine Marque   +4 more
openaire   +5 more sources

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Sub-pixel edge detection for structural health monitoring

, 2009
In structural engineering it is essential to monitor the health of structural members under various load conditions. Traditionally, engineers are required to travel on site to retrieve various test results.
Uy, Brian (R9735), Pap, Laurence (S26287), Xiang, Yang (R8881), Zou, Ju Jia (R10477)   +3 more
core  

The Role of Flow Couplers in Free Flap Monitoring: Evidence From a Systematic Review and Meta-analysis. [PDF]

Plast Reconstr Surg Glob Open
De Pellegrin L, Dietrich LG, Wölffer M, Olariu R, Zubler C, Lese I.   +5 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Spatially explicit power analysis reveals challenges for a long-term threatened species monitoring program in Australia. [PDF]

Ecol Appl
Menon V, Southwell D, Robley A, Rees MW, Wilkinson DP, Giljohann K, Pascoe J, Wintle B, Hradsky BA.   +8 more
europepmc   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source