Results 51 to 60 of about 8,356,133 (342)
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
The problem considered was that of estimating the temperature field in a contaminated region of soil, using measurements of electrical potential and current and also of temperature, at accessible points such as the wells and electrodes and the soil ...
Bohun, Sean C., Westbrook, Rex
core
Making tau amyloid models in vitro: a crucial and underestimated challenge
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Automated redaction of names in adverse event reports using transformer-based neural networks
Background Automated recognition and redaction of personal identifiers in free text can enable organisations to share data while protecting privacy. This is important in the context of pharmacovigilance since relevant detailed information on the clinical
Eva-Lisa Meldau+3 more
doaj +1 more source
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke+2 more
wiley +1 more source
Formulation of an evaluation index system of geological hazard data quality in China
This paper provides an exploratory study about data quality evaluation index system of geological hazard. To serve geological hazard research and national geological hazard prevention, select five dimensions of completeness, timeliness, accuracy ...
Chunrong YIN+6 more
doaj +1 more source
Optical monitoring system [PDF]
Instrument can measure optical transmission, reflectance, and scattering. This information can be used to identify changes in optical properties or deviations from required optical standards.
Fox, M. G.+3 more
core +1 more source
Towards security monitoring patterns [PDF]
Runtime monitoring is performed during system execution to detect whether the system’s behaviour deviates from that described by requirements. To support this activity we have developed a monitoring framework that expresses the requirements to be ...
Androutsopoulos, K.+2 more
core +2 more sources
Autophagy in cancer and protein conformational disorders
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Alaska's System for Monitoring Compliance with the Juvenile Justice and Delinquency Prevention Act [PDF]
Pursuant to Section 223(1)(15) of the Juvenile Justice and Delinquency Prevention Act of 1974 and 28 CFR Part 31.303(f), states are required to describe their plans and procedures for annually monitoring compliance with the Act.
Parry, David L.
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