Results 61 to 70 of about 795,289 (310)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Case study on accuracy comparison of digital twins developed for a heritage bridge via UAV photogrammetry and terrestrial laser scanning

open access: yes, 2021
Over the last decade, advanced remote technologies have been considerably utilised for digitisation of civil infrastructure assets, particularly bridges, and providing accurate data for indirect inspection and assessment through digital twins of their ...
Rashidi, Maria (R18339)   +5 more
core  

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

A Holistic Approach to Quantifying and Controlling the Accuracy, Performance and Availability of Machine Tools [PDF]

open access: yes, 2010
With today’s ever increasing demand for improved accuracy and faster material removal rates, CNC machine tool manufacturers and users are under pressure to supply and maintain machinery with a high degree of accuracy and performance.
Verma, Mayank   +10 more
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Diagnosing Eyewitness Accuracy [PDF]

open access: yes, 2015
Eyewitnesses frequently mistake innocent people for the perpetrator of an observed crime. Such misidentifications have led to the wrongful convictions of many people. Despite this, no reliable method yet exists to determine eyewitness accuracy.
Russ, Andrew
core  

Dosimetric accuracy at low monitor unit settings

open access: yesThe British Journal of Radiology, 1991
Abstract Dosimetric accuracies at low monitor units are evaluated for linear accelerators from various manufacturers. A large error is observed in the majority of the accelerators. The error can be positive or negative. Although the error can exceed 20% for the first few monitor units, it is usually less than 5% when more than 10 monitor
I J, Das, K R, Kase, V M, Tello
openaire   +2 more sources

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

open access: yesFEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková   +3 more
wiley   +1 more source

The illusion of accuracy: a critical analysis of continuous glucose monitoring systems quality assessment methods

open access: yesСахарный диабет
Continuous glucose monitoring (CGM) has been established as a method for self-assessment glucose levels in individuals with diabetes mellitus in the Russian Federation for more than 15 years.
M. V. Shestakova   +7 more
doaj   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

open access: yesFEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

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