Results 101 to 110 of about 5,419 (294)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Software for Trajectory Monitorization and Inertial Motion of Underwater Vehicles

open access: yes, 2017
RESUMEN: En este proyecto se presenta un software para la monitorización de la trayectoria y de los movimientos que se producen en un vehículo submarino no tripulado debido a la interacción con el medio.
Llano Sánchez, Saray
core  

Can we use magnesium for sedation in the intensive care unit for critically ill patients: Is it as effective as other sedatives?

open access: yes, 2019
Objectives: The aim of this prospective, randomized study was to investigate the effect of magnesium added to midazolam on the hemodynamics, transition time to a T-piece, mechanical ventilation duration, additional sedative-analgesic requirement using ...
Hergunsel, Gulstim Oya   +4 more
core   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

The analysis of the specific situationof Romania in the public policy making, implementation, monitorization and evaluationprocess at central level [PDF]

open access: yes
In this paper we analyzed the public policy planning and making process at central level in Romania. In recent years, significant progresses concerning this process which is coordinated by the General Secretariat of the Government were made.
George MOLDOVEANU, Mihaela PACESILA
core  

The importance of the management of anaesthesia during surgery for sacrococcygeal teratoma in the newborn Sakrokoksigeal teratomlu yenidoǧanda ameliyat esnasi{dotless}nda anestezi yönetiminin önemi

open access: yes, 2012
Sacrococcygeal teratoma is the most common germ cell tumor in newborn infants. Teratomas with unknown etiology can cause problems in the management of surgery and anaesthesia during operation since they can reach high pressure levels due to increased ...
Yildiz, Hüseyin   +5 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

A difficult intensive care unit monitorization case: a suicidal attempt at 13 years of age by hanging [PDF]

open access: yesDüşünen Adam Psikiyatri ve Nörolojik Bilimler Dergisi, 2016
Suicide among young population is a global challenge increasing over time. Family problems, drug addiction, increased risk of childhood depression may lead to suicidal attempts by hanging with a rope, which is a rarely selected method at younger ages ...
isa yildiz   +5 more
doaj  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

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