Results 261 to 270 of about 540,107 (356)

Safety, tolerability and pharmacokinetics of DNDI‐6148, a novel agent for leishmaniasis: A randomized, controlled, single ascending dose study in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aim The benzoxaborole derivative DNDI‐6148 is an antiparasitic agent with activity against multiple Leishmania protozoan species, including L. infantum and L. donovani, which cause visceral leishmaniasis. We investigated the safety, tolerability and pharmacokinetics of single oral doses of DNDI‐6148 in a randomized, parallel‐group, placebo‐controlled ...
Jean‐Yves Gillon, Sophie Delhomme, Delphine Launay, Séverine Blesson, Stéphanie Braillard, Pegah Maghdooni, Frauke Assmus, Richard Hoglund, Joel Tarning, Sabrina Loyau, Byron Arana, Mathilde Latreille‐Barbier, Yves Donazzolo   +12 more
wiley   +1 more source

Evolution of CEACAM1 N Domain Biologically Active Sites in Primates. [PDF]

Biology (Basel)
Skubitz KM, Zimmermann W.
europepmc   +1 more source

Low‐intervention clinical trials in Spain: Do they progress?

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Low‐Intervention Clinical Trials (LICTs) are generally pragmatic trials that investigate medicinal products already authorized for use. In 2014, simplified regulatory frameworks were introduced for LICTs with the aim of reducing regulatory burden and operational complexity, to foster non‐commercial clinical trials (NCCTs); the mandatory ...
Claudia Erika Delgado‐Espinoza, Mayro J. Cortés Pestana, Kristopher Amaro, Rosa M. Antonijoan, Caridad Pontes   +4 more
wiley   +1 more source

Propagation of Prediction Signals Revealed by Synchronous Oscillations in the Frontotemporal Network During Tone Omission in Macaque Monkeys. [PDF]

Eur J Neurosci
Suda Y, Tada M, Matsuo T, Kawasaki K, Kirihara K, Suzuki T, Hasegawa I, Kasai K, Uka T.   +8 more
europepmc   +1 more source

Polymorphism of the group-specific component in Japanese monkeys as revealed by two-dimensional gel electrophoresis.

, 1988
Shuichi Tsuchida, Kazuyoshi Uematsu, Emiko Nozawa, Atsushi Nagai, Shigenori Ikemoto   +4 more
openalex   +2 more sources

Population pharmacokinetics and dose–response relationships of mitoxantrone in children with acute myeloid leukaemia

British Journal of Clinical Pharmacology, EarlyView.
Background Information on mitoxantrone pharmacokinetics in children is lacking and reduced dosing regimens applied to infants are supported by limited scientific rationale. The current study characterized mitoxantrone pharmacokinetics in a childhood acute myeloid leukaemia patient population and provides a data‐informed assessment of dosing.
Andrew M. Brandon, Hinke Huisman‐Siebinga, Shelby Barnett, Paul Wetherell, Pamela Kearns, Brenda Gibson, Nicholas Heaney, Owen Smith, André Baruchel, Arnaud Petit, Andrew Moore, Kayode Ogungbenro, Alwin D. R. Huitema, Gareth J. Veal   +13 more
wiley   +1 more source

Aging-linked systemic lipid signature is reprogrammed by caloric restriction in rhesus monkeys. [PDF]

Mol Syst Biol
Abou Elhassan SI, Clark JP, Kuang D, Rhoads TW, Colman RJ, Coon JJ, Anderson RM, Overmyer KA.   +7 more
europepmc   +1 more source

Possible therapeutic repositioning of valproic acid: From epileptic seizures to acute kidney injury

British Journal of Clinical Pharmacology, EarlyView.
Valproic acid, an anticonvulsant, may be repositioned to prevent acute kidney injury due to ischemia followed by reperfusion. It preserves renal functions, electrolyte homeostasis and active sodium transport in kidney tubules, and blocks the onset of hypertension.
Danilo Alves‐Bezerra, Luiza B. Negreiros, Amaury Pereira‐Acácio, Isadora G. Almeida, João P. M. Veloso‐Santos, Jarlene A. Lopes, Glória Costa‐Sarmento, Humberto Muzi‐Filho, Adalberto Vieyra   +8 more
wiley   +1 more source

CAFFEINE-INDUCED OPIATE-LIKE WITHDRAWAL SIGNS IN MORPHINE-DEPENDENT MALE CYNOMOLGUS MONKEYS.

, 1994
Koichiro Fukuzaki, Hiroyuki Fukase, Takeshi Koja, Yoshiko Masubuchi, Masanao Hirai, Ryoichi Nagata, Scott. E. Lukash   +6 more
openalex   +1 more source