Results 51 to 60 of about 150,651 (268)

Augmenting and Assaying Nav1.1 Protein Quantity for Dravet Syndrome Therapy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Dravet Syndrome (DS) is a developmental and epileptic encephalopathy predominantly caused by heterozygous loss‐of‐function variants in SCN1A, which encodes Nav1.1. Conserved upstream open reading frames (uORFs) in SCN1A were validated to regulate translation in reporter assays, demonstrating the therapeutic viability of increasing Nav1.1 from ...
Aiswarya Saravanan, Jordan Safran, Anna Loughman, Grace Lin, Shivanshi Vaid, Dana Allababidi, Peter M. Tessier, Louis T. Dang   +7 more
wiley   +1 more source

Dopant Distribution in Ga‐Implanted CdO—A Correlative Microscopy and Molecular Dynamics Study

Advanced Functional Materials, EarlyView.
This work demonstrates that ion implantation offset angle could modulate carrier concentration and mobility in cadmium oxide thin films. Combining correlative microscopy workflow and molecular dynamics simulations, this study reveals the control of interfacial cluster density with tailoring implantation angles, and the optimum offset angle that ...
Morvarid Ghorbani, Bhaveshkumar Kamaliya, Maxwell J. Tolchin, Ryan W. Spangler, Youngji Kim, Joshua D. Caldwell, Jon‐Paul Maria, Nabil D. Bassim   +7 more
wiley   +1 more source

Will the Establishment of a National Park Protect More Suitable Habitats for the Qinling Golden Snub‐Nosed Monkey?

Ecology and Evolution
The Qinling Mountains, recognized as a biodiversity hotspot, are included in the national park construction plan, necessitating clear boundaries and critical habitats for endangered species, which are essential to fulfill the function of the national ...
Tong Wu, Xiaoxiao Shu, Xiaowei Wang, Haitao Zhao, Li Zhao, Shuaibin Shang, Yan Wang, Wei Li, Yi Ren, Weiwei Fu, Shujun He, Daibo Zhu, Bin Guo, Guiyuan Zhang, Chengliang Wang   +14 more
doaj   +1 more source

Thermoresponsive Soft and Self‐Anchoring Cuff Electrode for Chronic Peripheral Interfaces

Advanced Functional Materials, EarlyView.
A novel thermoresponsive, soft and self‐anchoring (TSSA) cuff electrode utilizing shape memory polymers achieves autonomous, sutureless peripheral nerve fixation. Driven by thermally induced pre‐strain and tissue adhesion, the device self‐closes and softens at body temperature, successfully minimizing mechanical mismatch. This adaptive platform ensures
Seungjun Lee, Byungwook Park, Jonghee Eun, Sohee Kim, Namsun Chou   +4 more
wiley   +1 more source

Neural Networks for Modeling Neural Spiking in S1 Cortex

Frontiers in Systems Neuroscience, 2019
Somatosensation is composed of two distinct modalities: touch, arising from sensors in the skin, and proprioception, resulting primarily from sensors in the muscles, combined with these same cutaneous sensors.
Alice Lucas, Tucker Tomlinson, Neda Rohani, Raeed Chowdhury, Raeed Chowdhury, Sara A. Solla, Sara A. Solla, Aggelos K. Katsaggelos, Lee E. Miller, Lee E. Miller, Lee E. Miller   +10 more
doaj   +1 more source

Intelligent Orthopedics: Machine Learning in Diagnosis of Bone Disease, Implants, and Bone Health Monitoring

Advanced Healthcare Materials, EarlyView.
Efficient recovery from traumatic or degenerative diseases is a great challenge, even after all the advancements in bone and cartilage regeneration. Machine learning (ML) algorithms have presented opportunities to enhance these aspects by accurately analyzing imaging data.
Maryam Kamaei, Hesam Mohammadi, Shamim Golafshan, Mojtaba Alehosseini, Mahsa Mohammadzadeh, Atefeh Golshirazi, Nasim Golafshan, Tatiane Eufrásio‐da‐Silva, Alireza Dolatshahi‐Pirouz, Gorka Orive   +9 more
wiley   +1 more source

Firing frequency maxima of fast-spiking neurons in human, monkey and mouse neocortex

Frontiers in Cellular Neuroscience, 2016
Cortical fast-spiking (FS) neurons generate high-frequency action potentials (APs) without apparent frequency accommodation, thus providing fast and precise inhibition.
Bo Wang, Bo Wang, Wei Ke, Jing Guang, Guang Chen, Luping Yin, Suixin Deng, Quansheng He, Yaping Liu, Ting He, Rui Zheng, Yanbo Jiang, Xiaoxue Zhang, Tianfu Li, Guoming Luan, Haidong D. Lu, Mingsha Zhang, Xiaohui Zhang, Yousheng Shu   +18 more
doaj   +1 more source

De Novo Autogenic Engineered Living Functional Materials

Advanced Materials, EarlyView.
A versatile platform for de novo autogenic engineered living materials is presented, leveraging protein mining, computational modeling, and synthetic biology. By reprogramming the Escherichia coli curli machinery with β‐solenoid proteins from non‐model bacteria, macroscopic biomaterials with enhanced mechanical properties, UV‐C irradiation protection ...
Hoda M. Hammad, Seth Swarnadeep, Erin C. Jackson, Nicolas Burns, Hongyu Wang, Harrison Priode, Robert B. Moore, Sanket Deshmukh, Avinash Manjula‐Basavanna, Anna M. Duraj‐Thatte   +9 more
wiley   +1 more source

Aggressive Behavior of Phayre’s Leaf Monkeys Towards Domestic Dogs in Cachar District of Assam, India

Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2015
Phayre’s leaf-monkeys (Trachipithecus phayrei) or Phayre’s langurs are old world monkeys that inhabit South-East Asian tropical forests. The species is under a severe threat due to large scale habitat destruction and disturbances by people living near ...
Mitrajit Deb, Pinaki Adhikary, Petr Sláma, Zdeněk Havlíček, Petr Řezáč, Parimal C. Bhattacharjee, Shubhadeep Roychoudhury   +6 more
doaj   +1 more source

Data‐Driven Materials Science for Energy‐Sustainable Applications

Advanced Materials, EarlyView.
Data‐driven approaches powered by artificial intelligence are transforming materials discovery for energy sustainability. This review examines how auto‐generated high‐quality materials databases and domain‐specific language models accelerate research in photovoltaics, thermoelectrics, batteries and magnetic materials. Applications involve extraction of
Jacqueline M. Cole
wiley   +1 more source