Results 181 to 190 of about 255,919 (307)

Engineering Biology Beyond Single Genes: Advances and Challenges in Multiplex Genome Editing

Animal Research and One Health, EarlyView.
Multiplex genome editing is transforming genome engineering from single‐gene perturbation to network‐level control, yet its broader application remains limited by challenges in gRNA array engineering, delivery technologies, and safety management. Emerging AI‐driven approaches are accelerating guide RNA design and CRISPR effector optimization for ...
Linli Wang, Yongbin Liu, Hongbing Han
wiley   +1 more source

Efficient production of cynomolgus monkeys via transabdominal uterine puncture embryo transfer†. [PDF]

Biol Reprod
Li Z, Dong Y, Chen X, Tian B, Si C, Ji W, Niu Y, Kang Y.   +7 more
europepmc   +1 more source

Arthroscopic Fixation of Unstable Adolescent Knee Osteochondritis Dissecans With Structural Tibial Cancellous Bone Autograft

Arthroscopy Techniques, EarlyView.
Abstract The treatment of knee osteochondritis dissecans in young patients remains challenging. Unstable or displaced lesions and those unresponsive to conservative management require surgical treatment. Because the articular surface morphology is complex and patient‐specific, preservation and fixation of the native osteochondritis dissecans fragment ...
Yuta Tachibana, Tomoya Nishikawa, Tomoyuki Shimoji, Tomoki Ohori, Hiroyuki Tanaka, Seiji Okada, Kazutaka Kinugasa   +6 more
wiley   +1 more source

High-sensitivity Cardiac Troponin I Changes Following Subcutaneous Needle Puncture, Restraint, and Venipuncture in Cynomolgus Monkeys. [PDF]

In Vivo
Taniguchi Y, Iwakiri T, Yoshikawa T, Yamada T, Kawaguchi H.   +4 more
europepmc   +1 more source

All‐Arthroscopic Trochlear Osteochondral Scaffold Matrix Implantation for Osteochondral Defects of the Femoral Trochlea

Arthroscopy Techniques, EarlyView.
Abstract The treatment of osteochondral defects via an aragonite‐based osteochondral scaffold has been established via mini‐arthrotomy. This report describes a variation of the established procedure to perform and complete the scaffold implantation in the femoral trochlea via a reproducible, all‐arthroscopic technique.
Matthew Varacallo, Jared Ham
wiley   +1 more source

How monkeys carve up the visual world. [PDF]

Elife
Wang B.
europepmc   +1 more source

Patellar Tendon Allograft Reconstruction Using Achilles Graft With Traversing Suprapatellar Cerclage Limbs

Arthroscopy Techniques, EarlyView.
Abstract Patellar tendon rupture and chronic extensor mechanism deficiency present significant reconstructive challenges, particularly in revision settings or when native tissue quality is poor. We describe a reproducible surgical technique for patellar tendon reconstruction using an Achilles allograft with traversing suprapatellar cerclage limbs. This
Ronak J. Mahatme, Shawn A. Moore, Nishanth Muthusamy, Brian M. Grawe, Joseph D. Lamplot, David L. Bernholt   +5 more
wiley   +1 more source

Somatotopic functional connectivity gradients in the monkey and human striatum. [PDF]

Imaging Neurosci (Camb)
Goda N, Chiken S, Koketsu D, Nambu A, Fukunaga M.   +4 more
europepmc   +1 more source

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

No Response to Inconsistently Experienced Inequity in Four Primate Species. [PDF]

Am J Primatol
Simmons SMV, Hopper LM, Paukner A, Freeman HD, Talbot CF, Lambeth SP, Schapiro SJ, Williams LE, Brosnan SF.   +8 more
europepmc   +1 more source