Results 131 to 140 of about 143,593 (306)

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, EarlyView.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

Conversational Democracy: Facilitating Children's ‘Unprompted Talk’ in Social Work Dialogues

Child &Family Social Work, EarlyView.
ABSTRACT In child and family social work dialogues, social workers address topics that are relevant to children's well‐being and safety. In doing so, they inevitably prioritize one conversational direction over another. This means that while one topic is being addressed, other possible topics are put on hold or are simply never developed.
Kristina Edman
wiley   +1 more source

Copy Number Variants in the 11p15.5 Associated Imprinting Disorders: An Attempt to Establish a Genotype–Phenotype Correlation

Clinical Genetics, EarlyView.
Copy number variations (CNVs) in 11p15.5 account for more than 2% of the molecular disturbances in the imprinting disorders Beckwith–Wiedemann and Silver–Russell syndrome. Their size and gene content vary, and therefore the impact on the phenotype is variable. Based on published data from > 220 carriers, an overview of the pathogenicity of 11p15.5 CNVs
Anastasia Maria Licata, Elke Botzenhart, Katja Kloth‐Stachnau, Thomas Eggermann   +3 more
wiley   +1 more source

Beyond the Rebel ‘Territorial Trap’: Governing Armed Sovereign Formations in Eastern Myanmar

Development and Change, EarlyView.
ABSTRACT Territorial control is a central concept in the study of civil wars and rebel governance. However, scholars often fall into a ‘territorial trap’, assuming that territorial control is either an outcome of or a precondition for armed governance. Based on immersive fieldwork in eastern Myanmar, this article traces how different spatial orderings ...
Tony Neil, Saw Day Chit Htoo
wiley   +1 more source

Integrating ecological feedbacks across scales and levels of organization

Ecography, EarlyView.
In ecosystems, species interact in various ways with other species, and with their local environment. In addition, ecosystems are coupled in space by diverse types of flows. From these links connecting different ecological entities can emerge circular pathways of indirect effects: feedback loops.
Benoît Pichon, Sonia Kéfi, Nicolas Loeuille, Ismaël Lajaaiti, Isabelle Gounand   +4 more
wiley   +1 more source

How a Monk Ought to Relate to his Neighbor

Greek, Roman, and Byzantine Studies, 2013
Several anecdotes in the Apophthegmata Patrum illustrate how the desert monks coped with the paradoxical situation of having to deal with other monks even while vowing to live alone.
John Wortley
doaj  

Laboratory Biology, Immature and Adult Morphology of Trichopria drosophilae (Perkins) (Hymenoptera: Diapriidae), Parasitoids of Drosophila Flies

Entomologia Experimentalis et Applicata, EarlyView.
This study investigates the laboratory biology and morphology of the parasitoid Trichopria drosophilae, which targets Drosophila flies, including the invasive Drosophila suzukii. Key findings include a detailed description of the parasitoid's egg, three larval instars, and pupal stage, as well as unique behaviors such as siblicide and encapsulation in ...
Alex Gumovsky, Jana Collatz, Lesia Tymochko, Lars Krogmann   +3 more
wiley   +1 more source

Peasants into Muslims: Poverty and conversions to Islam in Ottoman Bosnia

The Economic History Review, EarlyView.
Abstract Whilst economic historians have invested substantial effort into understanding the economic consequences of religion, they have invested less effort into understanding the determinants of religious affiliation. The lack of knowledge about determinants of religious affiliation seems particularly striking in the case of Southeastern Europe ...
Leonard Kukić, Yasin Arslantas
wiley   +1 more source

Community-based participatory research on Alzheimer's disease and related dementias among Tibetan Buddhist monks in South India: The Lifestyle Assessment and Monastic Aging Study (LAMAS). [PDF]

Alzheimers Dement
Namdul T, MacLehose R, Pasang T, Madesclaire O, Gyatso G, Henderson A, Buchwald D.   +6 more
europepmc   +1 more source

The commercialization of labour markets: Evidence from wage inequality in the Middle Ages

The Economic History Review, EarlyView.
Abstract This paper moves beyond the focus on ‘average’ wage trends in pre‐industrial economies by examining the broad diversity of pay rates and forms of remuneration across occupations and regions in medieval England. We find that whilst some workers enjoyed substantial growth in wage rates after the Black Death, there was a large group who ...
Jordan Claridge, Vincent Delabastita, Spike Gibbs   +2 more
wiley   +1 more source