Results 91 to 100 of about 36,008 (205)

The Sooner, the Better: Neuroprotective Strategies in Fetuses With Congenital Heart Disease

Prenatal Diagnosis, EarlyView.
ABSTRACT Congenital heart disease (CHD) is the most frequent congenital malformation at birth and is associated with neurodevelopmental impairments. Alterations in cardiovascular physiology can lead to reduced cerebral blood perfusion and oxygenation, which negatively affects brain growth and maturation.
Maaike Nijman, Mirthe E. M. van der Meijden, Johannes M. P. J. Breur, Raymond Stegeman, Nicolaas J. G. Jansen, Mireille N. Bekker, Manon J. N. L. Benders, Nathalie H. P. Claessens   +7 more
wiley   +1 more source

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

Activity of an oleanane-type tritrepenoid saponin from A. glycyphyllos on human recombinant MAO enzymes [PDF]

Pharmacia
For centuries, plants have been a leading point in the identification of potential therapeutic agents. Monoamine oxidase inhibition is a key mechanism in the treatment of various neurological and psychiatric diseases.
Aleksandar Shkondrov, Magdalena Kondeva-Burdina, Ivan Stambolov, Ilina Krasteva   +3 more
doaj   +3 more sources

Gene variants with suicidal risk in a sample of subjects with chronic migraine and affective temperamental dysregulation [PDF]

, 2012
BACKGROUND: Risk factors for suicide are at least partially heritable and functional polymorphisms of targeted genes have been suggested to be implicated in the pathogenesis of this phenomenon.
BORRO, Marina, D. A. Lamis, GENTILE, Giovanna, GIRARDI, Paolo, LALA, NOEMI, M. Innamorati, MARTELLETTI, Paolo, NEGRO, ANDREA, POMPILI, Maurizio, SERAFINI, Gianluca, SIMMACO, Maurizio   +10 more
core  

Molecular aspects of monoamine oxidase B [PDF]

, 2016
Monoamine oxidases (MAO) influence the monoamine levels in brain by virtue of their role in neurotransmitter breakdown. MAO B is the predominant form in glial cells and in platelets.
Ramsay, Rona Ruth
core   +1 more source

Bridging Psychological Stress and Skin Cellular Aging: Flavonoids as a Dual‐Action Therapeutic Strategy

Phytotherapy Research, EarlyView.
ABSTRACT Psychological stress (or simply “stress”) is a major contributor to chronic disease worldwide, affecting 35% of the global population, including younger generations. Furthermore, it plays a significant role in human premature aging; hence, its detrimental effects on people's health compel us to comprehend and control the ways in which ...
Marco Duarte, Sílvia Santos Pedrosa, P. Raaj Khusial, Ana Raquel Madureira   +3 more
wiley   +1 more source

Correlation of serum IgE with stress in Indian dromedaries affected with skin wounds [PDF]

Journal of Stress Physiology & Biochemistry, 2010
The present investigation was planned to explore stress induced changes in the levels of IgE by correlating them with the important parameters of stress like cortisol and free radical scavengers in the serum of Indian dromedaries.
A.K Kataria, N. Kataria, R. Maan
doaj  

Deprenyl in Tourette’s Syndrome and ADHD

Pediatric Neurology Briefs, 1996
The efficacy of deprenyl, a monoamine oxidase inhibitor, was evaluated in the treatment of ADHD in 24 children and adolescents with comorbid Tourette’s syndrome (TS) enrolled at the University of Rochester and Baylor College of Medicine.
J Gordon Millichap
doaj   +1 more source

Functional selectivity of GPCR-directed drug action through location bias. [PDF]

, 2017
G-protein-coupled receptors (GPCRs) are increasingly recognized to operate from intracellular membranes as well as the plasma membrane. The β 2 -adrenergic GPCR can activate G s -linked cyclic AMP (G s -cAMP) signaling from endosomes.
Conti, Marco, Huang, Bo, Irannejad, Roshanak, Mika, Delphine, Pessino, Veronica, von Zastrow, Mark, Wedegaertner, Philip B.   +6 more
core   +3 more sources

β‐Galactosidase Based Molecular Imaging for Visualization of Cellular Senescence

iRADIOLOGY, EarlyView.
Jiani Huang, Peili Cen, Hong Zhang, Yan Zhong   +3 more
wiley   +1 more source