Results 41 to 50 of about 49,705 (278)
Annals of Neurology, EarlyView.Cladribine tablets are approved for relapsing multiple sclerosis, mediating their clinical effect by moderately depleting lymphocytes. In a prospective, monocentric study including 22 patients completing 2 annual cycles of cladribine, B‐ and T‐cell receptor repertoires and relapse activity were assessed at baseline and after 24 months. T‐cell clonality
Tilman Schneider‐Hohendorf +8 more
wiley +1 more source
Introducing Preference Heterogeneity into a Monocentric Urban Model: an Agent-Based Land Market Model [PDF]
, 2008 This paper presents an agent-based urban land market model. We first replace the centralized price determination mechanism of the monocentric urban market model with a series of bilateral trades distributed in space and time.
Filatova, Tatiana +2 more
core +1 more source
Arthritis &Rheumatology, Accepted Article.Objective To evaluate the prognostic utility of circulating Interleukin‐18 (IL‐18) levels in predicting disease activity, macrophage activation syndrome (MAS), and disease course in Still's disease (SD) patients receiving first‐line IL‐1 inhibitors (IL‐1i).
Matteo Trevisan +8 more
wiley +1 more source
Low‐intervention clinical trials in Spain: Do they progress?
British Journal of Clinical Pharmacology, EarlyView.Abstract Aims Low‐Intervention Clinical Trials (LICTs) are generally pragmatic trials that investigate medicinal products already authorized for use. In 2014, simplified regulatory frameworks were introduced for LICTs with the aim of reducing regulatory burden and operational complexity, to foster non‐commercial clinical trials (NCCTs); the mandatory ...
Claudia Erika Delgado‐Espinoza +4 more
wiley +1 more source
Unravelling the spatial directionality of urban mobility
Nature CommunicationsAs it is central to sustainable urban development, urban mobility has primarily been scrutinised for its scaling and hierarchical properties. However, traditional analyses frequently overlook spatial directionality, a critical factor in city centre ...
Pengjun Zhao +4 more
doaj +1 more source
Monocentric or polycentric?: Defining morphological structure of Nuts-2 regions of Turkey from 2000 to 2016 [PDF]
Geographica Pannonica, 2018 The popularity of polycentricity has been increasing in recent years. European spatial planning literature and policy documents that emphasize the positive effects of polycentricity can be one of the reason increase in the popularity of the concept ...
Sat Aydan N.
doaj
British Journal of Clinical Pharmacology, EarlyView.Abstract Congenital ichthyoses (CI) are rare, inherited skin disorders characterized by hyperkeratosis, scaling and fissuring that significantly impair patients' quality of life. Treatment options are limited, with systemic retinoids reserved for severe cases owing to their adverse effect profile.
Holm Schneider +10 more
wiley +1 more source
Depressive symptoms as independent correlates of epilepsy‐related cognitive burden
Epilepsia, EarlyView.Abstract Objective This study was undertaken to assess the relationship between the severity of depression and anxiety symptoms and epilepsy‐related variables and cognitive burden in people with epilepsy (PwE), as assessed using EpiTrack. Methods We prospectively enrolled a cohort of PwE who underwent EpiTrack and evaluation by Generalized Anxiety ...
Biagio Maria Sancetta +10 more
wiley +1 more source
Defining Urban Centres using Alternative Data Sets
Findings, 2019 In growing cities, the evolution of urban form is partially motivated in principle by travel distance benefits. Evidence from travel data can support the categorisation of activity organisation as monocentric, polycentric or dispersed.
Emily Moylan, Somwrita Sarkar
doaj +1 more source
Monocentric experience of primary hyperparathyroidism surgery in Algeria
Surgery Open Science, 2021 Introduction: Primary hyperparathyroidism (PHPT) remains a relatively underdiagnosed disease in developing countries. The aim of this study was to assess the demographic, pathological, biochemical, and surgical characteristics of patients with primary ...
Souad Nouikes Zitouni, Professor
doaj +1 more source