Results 281 to 290 of about 1,226,593 (337)

Safety, Pharmacokinetics, and Immunogenicity of Astegolimab, an Anti-ST2 Monoclonal Antibody, in Randomized, Phase I Clinical Studies. [PDF]

Clin Transl Sci
Zhang W, Cheung D, Fong A, Brooks L, Grimbaldeston MA, Arjomandi A, Yang X, Dash A, Wong H, Parnes JR, Mohan D.   +10 more
europepmc   +1 more source

Targeted Inhibition of CD74+ Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression

Advanced Science, EarlyView.
This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng, Bo Yu, Lei Zhang, Zhaowen Xue, Lutian Yao, Qingjun Yang, Zitao Liu, Sizhi Wu, Yongquan Huang, Xiaofei Zheng, Huiying Guo, Songwei Huan, Tao Jiang, Huajun Wang, Yulong Wei, Tao Gui   +15 more
wiley   +1 more source

A First-in-Human, Single- and Multiple-Dose Study of APG777, a Half-Life-Extended Anti-IL-13 Monoclonal Antibody, in Healthy Volunteers. [PDF]

Clin Transl Sci
Lim XQ, Winter E, Nograles K, Xu J, Zhang ZQ, Thankamony S, Dillinger L, Dambkowski CL.   +7 more
europepmc   +1 more source

Predicting and evaluating monoclonal antibody protein-protein interactions and aggregation: a combined experimental and computational approach

Glenn M. Ferreira
openalex   +2 more sources

De Novo Gene Transcription of Connexin Mediates Cytoplasmic Fluid Exchange and Flocking Transitions in Physiological and Cancerous Epithelial Systems

Advanced Science, EarlyView.
EGF‐induced de novo transcription of connexins Cx26 and Cx31 promotes flocking behavior that fluidizes epithelia and enables coordinated collective migration. Connexin‐driven cytoplasmic exchange mechanistically links growth‐factor signaling to invasive dynamics.
Hind Abdo, Leonardo Barzaghi, Yuan Shen, Edoardo Bellini, Emanuele Martini, Serena Magni, Sara Barozzi, Fabrizio Orsenigo, Dario Parazzoli, Galina V. Beznoussenko, Jasmin Di Franco, Fabian Krautgasser, Jasmin Kaivola, Mario Cinquanta, Alessandro Lazzarin, Sara Sigismund, Johanna Ivaska, Roberto Cerbino, Giorgio Scita   +18 more
wiley   +1 more source

Therapeutic innovations in triple negative breast cancer: integrating molecular targeting and monoclonal antibody strategies. [PDF]

Front Oncol
Mir PA, Kumar N, Gupta SK, Kaur A, Farooq S, Sandhu GS, Kumar A.   +6 more
europepmc   +1 more source

Performance Evaluation of a HBsAg-Specific Immunoadsorbent Based on a Humanized Anti-HBsAg Monoclonal Antibody. [PDF]

Biomedicines
Gao S, Cai X, Yan T, Wang Y, Tao X.
europepmc   +1 more source

Monoclonal antibody potentiating gonadotropin activity in vitro and in vivo in male and female rats and in ewes. [PDF]

Reproduction
Kara E, Decourtye J, Dupuy L, Casteret S, Bouchard P, Frydman R, Maurel MC.   +6 more
europepmc   +1 more source

Development of AL101 (GSK4527226), a progranulin-elevating monoclonal antibody, as a potential treatment for Alzheimer's disease. [PDF]

Alzheimers Res Ther
Budda B, Mitra A, Park L, Long H, Kurnellas M, Bien-Ly N, Estacio W, Burgess B, Chao G, Schwabe T, Paul R, Kenkare-Mitra S, Rosenthal A.   +12 more
europepmc   +1 more source