Results 321 to 330 of about 2,681,651 (342)

Cuproptosis Signature Would Reveal the Acute‐Remitting Pattern in Patients with Neuromyelitis Optica Spectrum Disorder

Advanced Science, EarlyView.
Neuromyelitis optica spectrum disorder (NMOSD) has distinct acute‐remitting courses but lacks biomarkers for predicting relapse. Recent studies found cuproptosis‐related genes affect its course, and a model built accordingly can predict relapse to aid intervention.
Peidong Liu, Ruoyu Li, Xinlin Wang, Hui Li, Huiru Hu, Ang Shen, Wenping Zhu, Jiali Pan, Yanmeng Xing, Weiming Xia, Henan Jiao, Di Chen, Lixin Wu, Li Liu, Ju Liu, Bin Yu, Xianzhi Liu, Hongbo Liu   +17 more
wiley   +1 more source

Okanin Suppresses the Growth of Colorectal Cancer Cells by Targeting at Peroxiredoxin 5

Advanced Science, EarlyView.
Okanin suppresses colorectal cancer growth by directly targeting PRDX5. This natural compound selectively binds peroxiredoxin 5 (PRDX5), inhibiting its activity and inducing WSB1‐mediated degradation. PRDX5 loss elevates ROS, suppresses GPX4 via SIAH2, and further triggers cell death (apoptosis and ferroptosis).
Ji Zhong Zhao, Yuan Fei Li, Fu Kang Yuan, Meng Lu Zhao, Ya Wen Han, Jia Xin Wang, Qi Yang, Han Ying Ye, Yu Cheng Lu, Shao Chin Lee   +9 more
wiley   +1 more source

Prediction of Monoclonal Antibody Pharmacokinetics in Pediatric Populations Using PBPK Modeling and Simulation. [PDF]

Pharmaceutics
Zunino C, Gualano V, Zhou H, Lukacova V, Le Merdy M.   +4 more
europepmc   +1 more source

HERV‐K TM Subunit Elicits CD8+ T Cell Anergy and Tumor Immune Evasion via Targeting CD3 Coreceptor ε in AML and PDAC

Advanced Science, EarlyView.
Novel viral immune checkpoint K‐TM subunit is aberrantly expressed in CD8+ T cells and enriched in sera of cancer patients, inducing CD8+ T cell anergy and eliciting potent tumor immune escape in mouse model. Mechanistically, K‐TM directly targets and induces the phosphorylation of CD3ε receptor.
Mengyuan Li, Shuwen Zheng, Qinyuan Gong, Zhaoxing Wu, Wen Lei, Wanyue Cao, Ping Wang, Xuzhao Zhang, Wenbin Qian, Yun Liang, Ying Lu, Fenglin Li, Qi Zhang, Rongzhen Xu   +13 more
wiley   +1 more source

Identification and characterization of a target antigen recognized by the monoclonal antibody against Opisthorchis viverrini. [PDF]

PLoS One
Techasen A, Worasith C, Muengsaen D, Ponglong J, Mahalapbutr P, Kongtaworn N, Rungrotmongkol T, Khongsukwiwat K, Wongphutorn P, Wangboon C, Homwonk C, Chaiyadet S, Laha T, Suttiprapa S, Sakonsinsiri C, Sithithaworn P, Thanan R.   +16 more
europepmc   +1 more source

DKK3 Initially Preserves Acinar Integrity Through MEK‐Fos Signaling, but Later Switches to an Oncogenic Role in Pancreatic Cancer

Advanced Science, EarlyView.
In pancreatic cancer, the protein DKK3 is found to play a complex role: it initially slows early tumor growth but later promotes tumor aggressiveness. DKK3 expression evolves during progression and drives cancer severity by orchestrating cellular and molecular signaling pathways.
Dharini Srinivasan, Elodie Roger, Lukas Perkhofer, Eleni Zimmer, Thomas F.E. Barth, Julia P. Mosler, Anna Härle, Stephanie E. Weissinger, Nadine T. Gaisa, Peter Möller, Nico Fischer, Chantal Allgöwer, J.‐Matthias Löhr, Dirk Grimm, Thomas Seufferlein, Stefan Liebau, Ninel Azoitei, Michael K. Melzer, Frank Arnold, Johann Gout, Alexander Kleger   +20 more
wiley   +1 more source

Safety and tolerability of a novel monoclonal antibody cocktail for rabies post-exposure prophylaxis. [PDF]

NPJ Vaccines
Fotedar N, Ravish HS.
europepmc   +1 more source

Prophylactic and therapeutic neutralizing monoclonal antibody treatment prevents lethal yellow fever infection. [PDF]

JCI Insight
Rust LN, Ricciardi MJ, Lutz SS, Yusova S, Louw JJ, Yrizarry-Medina A, Biswas S, Fischer M, Barber-Axthelm A, Zilverberg G, Bailey L, Swanson T, Tonelli R, McElfresh GW, Rosen BC, Voigt TB, Panayiotou C, Mauter JT, Ghosh N, Meanor J, Godoy G, Axthelm M, Smedley J, Slifka MK, Kallas EG, Webb G, Zweig R, Labriola CS, Bimber BN, Sacha JB, Watkins DI, Burwitz BJ.   +31 more
europepmc   +1 more source

The physiological limits of bispecific monoclonal antibody tissue targeting specificity. [PDF]

MAbs
Sepp A, Stader F, Derbalah A, Liu C, Zyla A, Gardner I, Jamei M.   +6 more
europepmc   +1 more source

Rapid Elimination of Culturable SARS-CoV-2 With Intramuscular or Intravenous Administration of Antiviral Monoclonal Antibody Therapy. [PDF]

Open Forum Infect Dis
Deo R, Choudhary MC, Glover OT, Ignacio RB, Boucau J, Chew KW, Moser C, Currier JS, Eron JJ, Javan AC, Giganti MJ, Aga E, Gibbs M, Cohen T, Streicher K, Soboleva K, Fletcher CV, Daar ES, Greninger AL, Coombs RW, Fischer W, Hughes MD, Smith D, Wohl DA, Barczak AK, Li JZ.   +25 more
europepmc   +1 more source