Results 361 to 370 of about 712,808 (414)

KK2DP7 Stimulates CD11b+ Cell Populations in the Spleen to Elicit Trained Immunity for Anti‐Tumor Therapy

Advanced Science, EarlyView.
This study introduces KK2DP7, a dendrimer‐structured peptide adjuvant, as a tool to decode trained immunity's role in antitumor therapy. Splenic CD11b+ cells mediate tumor suppression via TLR2‐IRF7 activation and epigenetic reprogramming, validated by adoptive transfer experiments.
Rui Zhang, Lin Tang, Yusi Wang, Xuejing Zhou, Zhenyu Ding, Li Yang   +5 more
wiley   +1 more source

Single-cell transcriptome analysis reveals the dysregulated monocyte state associated with tuberculosis progression. [PDF]

BMC Infect Dis
Ma R, Yang W, Guo W, Zhang H, Wang Z, Ge Z.   +5 more
europepmc   +1 more source

Spleen-derived classical monocytes mediate lung ischemia-reperfusion injury through IL-1β [PDF]

, 2018
et al,, Gelman, Andrew E, Hsiao, Hsi-Min, Kreisel, Daniel, Lavine, Kory J, Li, Wenjun, Liu, Yongjian, Luehmann, Hannah P, Puri, Varun, Ruiz-Perez, Daniel, Scozzi, Davide, Spahn, Jessica H, Takahashi, Tsuyoshi, Tanaka, Satona, Turam, Cem   +14 more
core   +1 more source

Fish Swim Bladder‐Derived ECM Hydrogels Effectively Treat Myocardial Ischemic Injury through Immunomodulation and Angiogenesis

Advanced Science, EarlyView.
A unique hydrogel based on extracellular matrix from fish swim bladder, which is suitable for transcatheter delivery and possesses remarkable reparative capabilities for treating heart failure, is developed. It emerges as a multi‐effect factor profoundly influencing inflammation regulation, angiogenesis, and myocardial metabolism.
Yulong Fu, Canran Gao, Hailing Zhang, Jing Liu, Boxuan Li, Wei Chen, Xiuping Chen, Xue Lin, Ligang Fang, Zhihong Wang   +9 more
wiley   +1 more source

Association between systemic inflammation biomarkers and incident cardiovascular disease in 423,701 individuals: evidence from the UK biobank cohort. [PDF]

Cardiovasc Diabetol
Qin P, Ho FK, Celis-Morales CA, Pell JP.
europepmc   +1 more source

Synergistic Modulating of Mitochondrial Transfer and Immune Microenvironment to Attenuate Discogenic Pain

Advanced Science, EarlyView.
Gallic acid (GA) and copper ions self‐assemble to form nanoparticles, which are then modified with mitochondrial targeting peptides and gap junction modulator. These nanoparticles scavenge mitochondrial reactive oxygen species to induce M2 polarization and enhance intercellular mitochondrial transfer.
Xinzhou Wang, Zhenyu Guo, Linjie Chen, Jing Sun, Kenny Yat Hong Kwan, Morgan Jones, Yan Michael Li, Yangyang Hu, Xueqiang Wang, Pooyan Makvandi, Xiangyang Wang, Qiuping Qian, Yunlong Zhou, Aimin Wu   +13 more
wiley   +1 more source

The association between inflammatory indices in early pregnancy and the risk of gestational diabetes mellitus in Chinese population. [PDF]

BMC Pregnancy Childbirth
Qiu J, Song R, Chen L, Yang D, Cheng W, Zhu W.   +5 more
europepmc   +1 more source

Genetically Engineered IL12/CSF1R‐Macrophage Membrane‐Liposome Hybrid Nanovesicles for NIR‐II Fluorescence Imaging‐Guided and Membrane‐Targeted Mild Photothermal‐Immunotherapy of Glioblastoma

Advanced Science, EarlyView.
A theranostic nanoplatform is formulated with NIR‐II emissive lipophilic cyanine dye IRC18 to intercalate into genetically engineered IL12/CSF1R‐macrophage membrane‐liposome hybrid nanovesicles, which assists to achieve blood–brain barrier crossing, glioblastoma targeting, NIR‐II fluorescence imaging, image‐guided membrane‐targeted mild photothermal ...
Pengfei Chen, Yue Liu, Haiyan Huang, Menglong Li, Hui Xie, Shubham Roy, Jingsi Gu, Jian Jin, Kai Deng, Lixin Du, Bing Guo   +10 more
wiley   +1 more source

The phenotype of monocyte subtypes and expression of chemokine receptors in the Chronic Venous Insufficiency. [PDF]

Clinics (Sao Paulo)
Germano DB, Chiba LN, Ballerini APADC, Bussador do Amaral J, Shio MT, Alves JM, de Abreu DA, Nali LHDS, Fonseca FAH, Izar MC, Bachi ALL, França CN.   +11 more
europepmc   +1 more source

The Encapsulation Strategies for Targeted Delivery of Probiotics in Preventing and Treating Colorectal Cancer: A Review

Advanced Science, EarlyView.
This work summarizes the efficacy and mechanisms of probiotics in CRC treatment, providing a comprehensive overview of various encapsulation methods such as microcapsules, hydrogels, single‐cell nanocoatings, and nanofibers for targeted probiotic delivery to inflammatory sites, with particular emphasis on the potential advantages of emerging single ...
Hao Zhong, Jin Jiang, Muhammad Hussain, Haoxuan Zhang, Ling Chen, Rongfa Guan   +5 more
wiley   +1 more source