Results 81 to 90 of about 172 (116)
Monogenic Lupus: Dissecting Heterogeneity
Autoimmunity Reviews, 2019 Systemic lupus erythematosus (SLE) is a severe lifelong multisystem autoimmune disease characterized by the presence of autoantibodies targeting nuclear autoantigens, increased production of type I interferon and B cell abnormalities. Clinical presentation of SLE is extremely heterogeneous and different groups of disease are likely to exist.
Sulliman Ommar Omarjee +2 more
exaly +6 more sources
Clinical Rheumatology, 2022 Abstract ObjectiveTo evaluate the application of the EULAR/ACR-2019 criteria to monogenic lupus patients and compare its performance against the SLICC-2012 criteria. Methods In a multicenter retrospective cohort study, consecutive patients with monogenic lupus from three tertiary lupus clinics were enrolled. The diagnosis of monogenic lupus was
Reem Abdwani +2 more
exaly +4 more sources
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Current Rheumatology Reports, 2016
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease known for its clinical heterogeneity. Over time, new insights into the complex genetic origin of SLE have started to explain some of this clinical variability. These findings, reviewed here, have also yielded important understanding in the immune mechanisms behind SLE pathogenesis ...
Mindy S Lo
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Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease known for its clinical heterogeneity. Over time, new insights into the complex genetic origin of SLE have started to explain some of this clinical variability. These findings, reviewed here, have also yielded important understanding in the immune mechanisms behind SLE pathogenesis ...
Mindy S Lo
exaly +3 more sources
New Horizons in the Genetic Etiology of Systemic Lupus Erythematosus and Lupus-Like Disease: Monogenic Lupus and Beyond [PDF]
Journal of Clinical Medicine, 2020 Systemic lupus erythematosus (SLE) is a clinically and genetically heterogeneous autoimmune disease. The etiology of lupus and the contribution of genetic, environmental, infectious and hormonal factors to this phenotype have yet to be elucidated. The most straightforward approach to unravel the molecular pathogenesis of lupus may rely on studies of ...
Micol Romano +2 more
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Monogenic Systemic Lupus Erythematosus: Insights in Pathophysiology
Rheumatology International, 2018Systemic lupus erythematosus (SLE) is a complex disease with different genetic, immunologic, and environmental factors contributing to the pathogenesis. Monogenic SLE could help us understand the main phases of immune dysregulation in SLE. The aim of this review is to summarize the current knowledge on monogenic SLE with the implications of the ...
Ezgi Batu
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Analysis of Five Cases of Monogenic Lupus Related to Primary Immunodeficiency Diseases
Inflammation Research, 2021We studied five cases of PID-related monogenic lupus to explore the characteristics.Among 42 cases of PID patients between 2017-2020, 5 patients were diagnosed as PID-related monogenic lupus, including 2 males and 3 females, with age range from 2 years 3 months to 13 years old.DMARDs, biological agents and stem cell transplantation were used to treat ...
yingjie Xu, Gaixiu Su, Jianming Lai
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Phenotype and disease course differences in monogenic and sporadic childhood lupus
Lupus, 2023Objective To report the differences in phenotypic characteristics, disease course, and outcome in monogenic and sporadic childhood lupus (SC-lupus) from a single tertiary childhood lupus clinic. Methods A descriptive, observational ...
Sulaiman M Al-Mayouf +2 more
openaire +2 more sources
Monogenic Lupus: It's All New!
Current Opinion in Immunology, 2017Monogenic lupus is rare, but its study has contributed immensely to a better understanding of the pathogenesis of systemic lupus erythematosus. The first forms identified were inherited complement deficiencies, which predisposed to lupus due to impaired tolerance, and aberrant clearance of apoptotic bodies and immune complexes. In recent years, several
Kathleen E. Sullivan
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Single-Centre Comparison of Non-Familial, Familial and Monogenic Lupus
RheumatologyAbstract Objectives There is a significant genetic contribution to systemic lupus erythematosus (SLE). Monogenic SLE is a distinct form of SLE. We investigated whether familial or known monogenic lupus cases are distinguishable from non-familial lupus by clinical or laboratory phenotype in a ...
Jalila Alshekaili, Samiya Al-Rashdi
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Monogenic Lupus: Tracing the Therapeutic Implications From Single Gene Mutations
Clinical Immunology, 2023Monogenic lupus, a distinctive variant of systemic lupus erythematosus (SLE), is characterized by early onset, family-centric clustering, and heightened disease severity. So far, over thirty genetic variations have been identified as single-gene etiology of SLE and lupus-like phenotypes.
Ruihan Tang, Xiuzhi Jia
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