Results 51 to 60 of about 561 (135)
JIMD Reports, Volume 65, Issue 4, Page 239-248, July 2024.Abstract Familial chylomicronemia syndrome (FCS) is a rare disorder of triglyceride (TG) metabolism caused by loss of function variants in one of five known canonical genes involved in chylomicron lipolysis and clearance—LPL, APOC2, APOA5, LMF1, and GPIHBP1. Pathogenic variants in LPL, which encodes the hydrolytic enzyme lipoprotein lipase, account for
Oliver Heath +10 more
wiley +1 more source
Two successful pregnancies ‐in patients taking Volanesorsen for familial chylomicronemia syndrome
JIMD Reports, Volume 65, Issue 4, Page 249-254, July 2024.Abstract Familial chylomicronemia syndrome (FCS) is a rare inherited disorder characterized by severe hypertriglyceridemia, posing a heightened risk of acute pancreatitis. Recently, Volanesorsen, an APOC3 antisense oligonucleotide, gained approval for FCS treatment in the UK.
Subadra Wanninayake +5 more
wiley +1 more source
Monogenic differential calculus [PDF]
Transactions of the American Mathematical Society, 1991 In this paper we study differential forms satisfying a Dirac type equation and taking values in a Clifford algebra. For them we establish a Cauchy representation formula and we compute winding numbers for pairs of nonintersecting cycles in R m {\mathbb {R}^m} as residues of ...
openaire +1 more source
On index divisors and monogenity of certain sextic number fields defined by $x^6+ax^5+b$
, 2022 The main goal of this paper is to provide a complete answer to the Problem 22 of Narkiewicz \cite{Nar} for any sextic number field $K$ generated by a complex root $\alpha$ of a monic irreducible trinomial $F(x) = x^6+ax^5+b \in \mathbb{Z}[x]$.
Fadil, Lhoussain El, Kchit, Omar
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Non-monogenity of certain quintic number fields defined by trinomials
Annals of the Alexandru Ioan Cuza University - MathematicsLet K be a number field generated by a complex root θ of an irreducible trinomial F(x) = x 5 + ax3 + b ∈ Z[x], where ab ̸= 0. In this paper, we provide some explicit conditions on a and b for which 2 divides the index of K.
H. Ben Yakkou
semanticscholar +1 more source
Monogenic human obesity syndromes
Recent Progress in Hormone Research, 2004 Over the past decade we have witnessed a major increase in the scale of scientific activity devoted to the study of energy balance and obesity. This explosion of interest has, to a large extent, been driven by the identification of genes responsible for murine obesity syndromes, and the novel physiological pathways revealed by those genetic discoveries.
I S, Farooqi, S, O'Rahilly
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On index divisors and monogenity of certain octic number fields defined by
Ukrains'kyi Matematychnyi ZhurnalUDC 511 For any octic number field K generated by a root α of a monic irreducible trinomial F ( x ) = x 8 + a x 3 + b ∈ ℤ [ x ] and for every rational prime p , we show when p divides the index ...
O. Kchit
semanticscholar +1 more source
Integral bases and monogenity of pure fields [PDF]
, 2021 Gaál, István, Remete, László
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On common index divisors and monogenity of certain number fields defined by x^{5}+ax+b
Boletim da Sociedade Paranaense de MatemáticaLet K = Q(α) be a number field, where α satisfies the monic irreducible polynomial F (x) = x5 + ax + b belonging to Z[x]. The purpose of this paper is to caracterise when a prime p is a common index divisor of K.
Omar Boughaleb, Karim Saber
semanticscholar +1 more source
, 2022 We say that a monic polynomial $f(x)\in {\mathbb Z}[x]$ of degree $N$ is monogenic if $f(x)$ is irreducible over ${\mathbb Q}$ and \[\{1,\theta,\theta^2,\ldots, \theta^{N-1}\}\] is a basis for the ring of integers of ${\mathbb Q}(\theta)$, where $f ...
Jones, Lenny
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