Results 61 to 70 of about 239,484 (302)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

Azobenzenes and dithiocarbamates in molecular film devices [PDF]

open access: yes, 2012
The “top-down” approach to improve the performance of small electronic devices is becoming more and more challenging due to economic and engineering restrictions. Thus, researchers seek for alternatives towards efficient, smaller and faster devices. The “
Reinders, Federica
core   +1 more source

Mechanoresponse of curved epithelial monolayers lining bowl-shaped 3D microwells [PDF]

open access: yes
peer reviewedThe optimal functioning of many organs relies on the curved architecture of their epithelial tissues [1]. However, the mechanoresponse of epithelia to changes in curvature remains misunderstood.
Versaevel, Marie   +3 more
core   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

open access: yesFEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai   +8 more
wiley   +1 more source

Monolayers of linear saturated succinate polyesters at air-liquid interfaces

open access: yes, 1961
The surface pressure-area isotherms at 25C are reported for some linear saturated polyesters spread as monolayers at air-aqueous interfaces. Monolayers of poly(ethylene succinate), poly(pentamethylene succinate), and poly(neopentyl succinate) were ...
Lee, Wendell M.; Shereshefsky, J. Leon; Stromberg, Robert R.
core   +1 more source

Modification of 316L Stainless Steel, Nickel Titanium, and Cobalt Chromium Surfaces by Irreversible Immobilization of Fibronectin: Towards Improving the Coronary Stent Biocompatibility

open access: yesMolecules
An extracellular matrix protein, fibronectin (Fn), was covalently immobilized on 316L stainless steel, L605 cobalt chromium (CoCr), and nickel titanium (NiTi) surfaces through an 11-mercaptoundecanoic acid (MUA) self-assembled monolayer (SAM) pre-formed ...
Hesam Dadafarin   +4 more
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

open access: yesFEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas   +6 more
wiley   +1 more source

From self assembled monolayers to clickable gold nanoparticles [PDF]

open access: yes, 2014
The aim of the present PhD thesis was the investigation of the behavior of gold nanoparticle stabilizing oligo thioether ligands on gold surfaces and further on to develop a protocol for the directed assembly of mono functionalized gold nanoparticle into
Sander, Fabian
core   +1 more source

Gold Nanoparticles Monolayer Based Field‐Effect Molecular Sensors

open access: yesAdvanced Electronic Materials
The rapid and efficient sensing mechanism of molecules and bimolecular species is crucial for healthcare, biomedical, and safety applications. Such sensors need to be robust and able to measure low concentrations of molecular species.
Yawar Abbas   +5 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

open access: yesFEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks   +4 more
wiley   +1 more source

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