Results 91 to 100 of about 59,085 (291)
Animal Models and Experimental Medicine, EarlyView.Transcriptome sequencing identified secreted phosphoprotein 1 (SPP1) as a crucial target through which methylophiopogonanone A (MOA) ameliorates pulmonary fibrosis. Molecular docking and microscale thermophoresis (MST) assays confirmed a favorable binding affinity between MOA and SPP1.
Fan Yang +10 more
wiley +1 more source
Annals of Neurology, EarlyView.Objective The extent of neuronal loss in Parkinson's disease (PD) and the pathogenic processes underlying neuronal dysfunction and loss remain poorly understood. Here, we analyzed the expression of key molecules representing different cell death signaling pathways and their association with Lewy pathology, dopaminergic (DA) neuron loss and stage of PD ...
Yue Jing Heng +3 more
wiley +1 more source
Advanced NanoBiomed Research, EarlyView.Glioblastoma mortality is driven by cell invasion and therapeutic resistance. We report a cancer engineering approach to evaluate the behavior of heterogeneous cohorts of temozolomide resistant and responsive GBM cells. We show the effect of physiologically‐relevant metronomic dosing on ensemble drug response and invasion.
Victoria A. Kriuchkovskaia +5 more
wiley +1 more source
Gold nano-particle modified silica monolithic micro-columns for selected chromatographic and biological applications. [PDF]
, 2011 Monolithic microcolumns and especially silica monoliths are showing several advantages compared to classical particle packed and organic polymeric monolithic columns: ease of production and functionalisation, excellent mechanical and thermal stability ...
Clarke, Paul A. +5 more
core
A question of hierarchy: matter effects with atmospheric neutrinos and anti-neutrinos
, 2004 It is by now established that neutrinos mix, have (different) non-zero masses, and therefore oscillate. The oscillation parameters themselves, however, are not all well-known. An open problem is that of the neutrino mass hierarchy.
A. Para +8 more
core +1 more source
Archaeological Prospection, EarlyView.ABSTRACT The Carnac alignments in Morbihan (France) are among the most famous Neolithic sites of the world. Paradoxically, they have benefited little from a thorough renewal of archaeological data over the past century. There are many reasons for this, but it is mainly because the site has been regarded more as a monument to visit and protect than as ...
Guillaume Bruniaux +6 more
wiley +1 more source
New platform for simple and rapid protein-based affinity reactions
Scientific Reports, 2017 We developed a spongy-like porous polymer (spongy monolith) consisting of poly(ethylene-co-glycidyl methacrylate) with continuous macropores that allowed efficient in situ reaction between the epoxy groups and proteins of interest.
Kei Kubota +4 more
doaj +1 more source
Journal of the Association for Information Science and Technology, Volume 76, Issue 4, Page 649-664, April 2025.Abstract Many theories of human information behavior (HIB) assume that information objects are in text document format. This paper argues four important HIB theories are insufficient for describing users' search strategies for data because of assumptions about the attributes of objects that users seek.
Anthony J. Million +3 more
wiley +1 more source
Platform, a Journal of Engineering, 2017 Obstructions placed to the flow have a significant effect on mixing of the fluids, particularly in the miniaturized scales. In this study, the impact of variation in axially aligned wire assembly was investigated for mixing of nitrogen ...
Mohd Zamri Abdullah, Salman Kashif
doaj