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Prognostic value of CSF IgG in monosymptomatic optic neuritis
1984The frequency with which patients with monosymptomatic optic neuritis develop multiple sclerosis (MS) is still under discussion. On the basis of clinical examinations, figures vary from 11.5 to 85%1. Various attempts have been made to study parameters which might influence the risk.
H. I. Schipper +3 more
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European Journal of Neurology, 1997
To evaluate various MRI criteria we studied a representative group of 149 consecutive patients below 50 years with acute monosymptomatic optic neuritis (AMON), a frequent first manifestation of multiple sclerosis (MS). The presence, number, size, and localization of areas of increased signal (AIS) on T2‐weighted brain MRIs obtained at 1.5 T were ...
J. L. Frederiksen +3 more
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To evaluate various MRI criteria we studied a representative group of 149 consecutive patients below 50 years with acute monosymptomatic optic neuritis (AMON), a frequent first manifestation of multiple sclerosis (MS). The presence, number, size, and localization of areas of increased signal (AIS) on T2‐weighted brain MRIs obtained at 1.5 T were ...
J. L. Frederiksen +3 more
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Multiple Sclerosis Journal, 1998
Twenty-seven patients with acute monosymptomatic optic neuritis were randomly selected from a population-based cohort of patients extensively screened for known etiologies of ON. Paired serum and CSF obtained median 20 days from onset were examined for oligoclonal IgG, free kappa and free lambda chains, and virus-specific oligoclonal IgG antibodies by
J L, Frederiksen, C J, Sindic
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Twenty-seven patients with acute monosymptomatic optic neuritis were randomly selected from a population-based cohort of patients extensively screened for known etiologies of ON. Paired serum and CSF obtained median 20 days from onset were examined for oligoclonal IgG, free kappa and free lambda chains, and virus-specific oligoclonal IgG antibodies by
J L, Frederiksen, C J, Sindic
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Multiple Sclerosis Journal, 2008
There is emerging evidence that multiple sclerosis (MS), the hypothalamic sleep-wake regulating neuropeptide hypocretin-1 (hcrt-1) and the sleep disorder narcolepsy may be connected. Thus, the major pathophysiological component of narcolepsy is lack of hcrt-1.
Knudsen, S +5 more
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There is emerging evidence that multiple sclerosis (MS), the hypothalamic sleep-wake regulating neuropeptide hypocretin-1 (hcrt-1) and the sleep disorder narcolepsy may be connected. Thus, the major pathophysiological component of narcolepsy is lack of hcrt-1.
Knudsen, S +5 more
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Journal of Neurology, 2015
Optic neuritis (ON) is a common first symptom of MS and only few studies have thus far investigated vitamin D at this early stage of MS. The objectives of the study were to examine total 25-hydroxyvitamin D levels (25HVITDL) in patients in acute (A) ON and to determine whether 25HVITD levels in AON (1) predict risk of RRMS and (2) are associated with ...
Gorm, Pihl-Jensen +1 more
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Optic neuritis (ON) is a common first symptom of MS and only few studies have thus far investigated vitamin D at this early stage of MS. The objectives of the study were to examine total 25-hydroxyvitamin D levels (25HVITDL) in patients in acute (A) ON and to determine whether 25HVITD levels in AON (1) predict risk of RRMS and (2) are associated with ...
Gorm, Pihl-Jensen +1 more
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Prognostic Value of Magnetic Resonance Imaging in Monosymptomatic Optic Neuritis
Ophthalmology, 1996Magnetic resonance imaging is able to depict lesions in the optic nerve in the acute stage of monosymptomatic optic neuritis. Most patients have lesions located intraorbitally, intracanalicularly, and/or intracranially. The goal of this study is to determine whether these lesions resolve after visual recovery, change in length or localization, or could
S, Dunker, W, Wiegand
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Multiple Sclerosis Journal, 1995
We investigated two short tandem tetranudeotide (TGGA) repeat polymorphisms upstreams of the myelin basic protein (MBP) gene. The region was amplified by the polymerase chain reaction (PCR) and the two repeat systems were separated by cutting with the restriction enzyme NlaJM.
Nellemann, L J +2 more
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We investigated two short tandem tetranudeotide (TGGA) repeat polymorphisms upstreams of the myelin basic protein (MBP) gene. The region was amplified by the polymerase chain reaction (PCR) and the two repeat systems were separated by cutting with the restriction enzyme NlaJM.
Nellemann, L J +2 more
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1999
Many patients with acute unilateral optic neuritis (ON) develop later multiple sclerosis (MS), the risk varying widely between 35% and 75% (McDonald 1983). Many MS and ON patients are subject to abnormalities of eye movements (Reulen et al 1983).
E. Tsironi +3 more
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Many patients with acute unilateral optic neuritis (ON) develop later multiple sclerosis (MS), the risk varying widely between 35% and 75% (McDonald 1983). Many MS and ON patients are subject to abnormalities of eye movements (Reulen et al 1983).
E. Tsironi +3 more
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[Role of nuclear magnetic resonance imaging in the diagnosis of monosymptomatic optic neuritis].
Klinische Monatsblatter fur Augenheilkunde, 198834 patients with monosymptomatic optic neuritis were examined ophthalmologically and by magnetic resonance imaging (MRI). In 18 patients subclinical lesions with a high MRI signal intensity were found. The distribution of these lesions was similar to that seen in multiple sclerosis.
R, Guthoff, B, Terwey, L, Brägelmann
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