Results 71 to 80 of about 46,283 (291)

Genetics Influences Telomere Length in Parkinson's Disease: A Study in Monozygotic Discordant Twins

Movement Disorders, EarlyView.
Abstract Background Parkinson's disease (PD) results from complex interactions among environmental, genetic, and aging factors. Telomeres, which ensure chromosome stability, naturally shorten with cell division, contributing to aging and cellular senescence.
Letizia Straniero, Valeria Rimoldi, Emanuele Cereda, Giulia Soldà, Daniela Calandrella, Stefano Duga, Samanta Mazzetti, Graziella Cappelletti, Ioannis U. Isaias, Gianni Pezzoli, Rosanna Asselta   +10 more
wiley   +1 more source

Generation and characterization of human-derived iPSC lines from three pairs of monozygotic twins discordant for Parkinson's disease

Stem Cell Research, 2019
Despite a genetic component in the development of Parkinson’s disease (PD), monozygotic twin pairs often display discordance for PD. Here, we describe the generation of six human induced pluripotent stem cell (iPSC) lines from dermal fibroblasts of three
Marija Dulovic-Mahlow, Agnieszka Lukomska, Sokhna Haissatou Diaw, Alexander Balck, Max Borsche, Karen Grütz, Insa Lenz, Franziska Rudolph, Katja Lohmann, Christine Klein, Philip Seibler   +10 more
doaj  

Evaluation of Induced Pluripotent Stem Cell‐Derived Dopaminergic Neurons from Siblings with Gaucher Disease Discordant for Parkinsonism

Movement Disorders, EarlyView.
Abstract Background In Gaucher disease (GD), glucocerebrosidase (GCase) deficiency results from biallelic pathogenic GBA1 variants. While GBA1 variants are a major risk factor for Parkinson's disease (PD), most patients with GD never develop parkinsonism.
Ellen Hertz, Krystyna Rytel, Gani Perez, Ying Hao, Ziyi Li, Charis Ma, Kate Andersh, Yue Andy Qi, Emory Ryan, Grisel Lopez, Nahid Tayebi, Ellen Sidransky, Yu Chen   +12 more
wiley   +1 more source

Is humn mating adventitious or the result of lawful choice? A twin study of mate selection. [PDF]

, 1993
Inventory data on a large sample of middle-aged twins and their spouses confirmed that spousal pairs are consistently but weakly similar on traits of personality, interests, talents, and attitudes.
Lykken, D.T., Tellegen, A.
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Genetic and environmental contributions to the associations between midlife personality and late‐life metabolic health

Obesity, EarlyView.
Abstract Objective Personality traits such as conscientiousness and emotional stability are consistently linked with better metabolic health, but there is limited evidence on the etiology of these associations and their robustness across the life‐span. Methods Therefore, we estimated phenotypic, genetic, and unique environmental associations of traits ...
Colin D. Freilich, Jacob J. Kunkel, Keely A. Dugan, Elise J. Vomacka, Adolfo G. Cuevas, Kristian Markon, Matt McGue, Glenn I. Roisman, Robert F. Krueger   +8 more
wiley   +1 more source

Genetic diversity and population structure of pedunculate oaks (Quercus robur) in Wytham Woods

PLANTS, PEOPLE, PLANET, EarlyView.
Genetic diversity underpins forest resilience and adaptation, yet centuries of human activity have reshaped woodland ecosystems worldwide. We studied the population genetics of pedunculate oaks (Quercus robur) in Wytham Woods, UK, across stands with different ages and management histories.
Tin Hang Hung, Elias Formaggia, Lucy Morley, Keith Kirby, Roberto Salguero‐Gómez, Ben C. Sheldon, John J. MacKay   +6 more
wiley   +1 more source

Twin Acardiac: Case Reported From Ethiopia

Clinical Case Reports
Acardiac twinning is a rare congenital anomaly in monozygotic twin pregnancies, caused by abnormal placental vascular anastomosis. We present a case of monochorionic twinning: Twin A was a heterogeneous mass with no head or cardiac activity, while Twin B
Ebisa Erena muleta, Girma Geta, Awel Temema Dube, Kasu Hailu Seifu   +3 more
doaj   +1 more source

The importance of systemic inflammatory response measurements as pretransplant risk factors for outcome after allogeneic haematopoietic cell transplantation

British Journal of Haematology, EarlyView.
In oncological patients SIR measures like the mGPS have great impact on prognosis at starting therapy. We recorded at admission for allo‐HCT the mGPS in 2201 patients: score 0 CRP/sALB normal; score 1 CRP >10mg/dl; score 2 CRP >10mg/dl + sALB <35g/L. Multivariate analysis revealed a significant impact with a low GPS score for OS: mGPS 1 vs.
Hartmut Bertz, Jörg Sahlmann, Donald C. McMillan, Claudia Wehr, Jesus Duque‐Afonso, Kristina Maas‐Bauer, Ralph Wäsch, Julia Nikolaychuk, Christine Greil, Jann Arends, Jürgen Finke, Robert Zeiser   +11 more
wiley   +1 more source

Kidney transplant from a monozygotic twin living donor with no maintenance immunosuppression

Nefrología (English Edition), 2015
Standard immunosuppression is used in about 60% of patients receiving kidney grafts from their monozygotic twins living donor although an alloimmune response can not take place.
Ana Sánchez-Escuredo, Alberto Barajas, Ignacio Revuelta, Miquel Blasco, Federic Cofan, Núria Esforzado, María José Ricart, Vicens Torregrosa, Josep Maria Campistol, Federic Oppenheimer, Fritz Diekmann   +10 more
doaj   +1 more source

Does Early Life Health Predict Schooling Within Twin Pairs? [PDF]

A large number of studies in labor economics estimate the returns to schooling using data on monozygotic twins, under the assumption that educational attainment is random within twin pairs. This exogeneity assumption has been commonly questioned, however,
Lundborg, Petter, Nilsson, Anton, Rooth, Dan-Olof   +2 more
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