Results 101 to 110 of about 349,469 (338)

A placebo-controlled trial of folic acid and betaine in identical twins with Angelman syndrome. [PDF]

, 2019
BackgroundAngelman syndrome (AS) is a neurodevelopmental disorder that is caused by maternal genetic deficiency of a gene that encodes E6-AP ubiquitin-protein ligase (gene symbol UBE3A) mapping to chromosome 15q11-q13.
Anselm, Irina, Bacino, Carlos A, Bichell, Terry Jo, Bird, Lynne M, Golden, Stephanie, Han, Julia, Kimonis, Virginia, Peters, Sarika U, Waisbren, Susan   +8 more
core  

Genetic diversity and population structure of pedunculate oaks (Quercus robur) in Wytham Woods

PLANTS, PEOPLE, PLANET, EarlyView.
Genetic diversity underpins forest resilience and adaptation, yet centuries of human activity have reshaped woodland ecosystems worldwide. We studied the population genetics of pedunculate oaks (Quercus robur) in Wytham Woods, UK, across stands with different ages and management histories.
Tin Hang Hung, Elias Formaggia, Lucy Morley, Keith Kirby, Roberto Salguero‐Gómez, Ben C. Sheldon, John J. MacKay   +6 more
wiley   +1 more source

Is humn mating adventitious or the result of lawful choice? A twin study of mate selection. [PDF]

, 1993
Inventory data on a large sample of middle-aged twins and their spouses confirmed that spousal pairs are consistently but weakly similar on traits of personality, interests, talents, and attitudes.
Lykken, D.T., Tellegen, A.
core  

Monozygotic twins discordant for constitutive BRCA1 promoter methylation, childhood cancer and secondary cancer

Epigenetics, 2012
We describe monozygotic twins discordant for childhood leukemia and secondary thyroid carcinoma. We used bisulfite pyrosequencing to compare the constitutive promoter methylation of BRCA1 and several other tumor suppressor genes in primary fibroblasts ...
D. Galetzka, T. Hansmann, N. El Hajj, E. Weis, B. Irmscher, Marco Ludwig, B. Schneider-Rätzke, N. Kohlschmidt, V. Beyer, O. Bartsch, U. Zechner, C. Spix, T. Haaf   +12 more
semanticscholar   +1 more source

The importance of systemic inflammatory response measurements as pretransplant risk factors for outcome after allogeneic haematopoietic cell transplantation

British Journal of Haematology, EarlyView.
In oncological patients SIR measures like the mGPS have great impact on prognosis at starting therapy. We recorded at admission for allo‐HCT the mGPS in 2201 patients: score 0 CRP/sALB normal; score 1 CRP >10mg/dl; score 2 CRP >10mg/dl + sALB <35g/L. Multivariate analysis revealed a significant impact with a low GPS score for OS: mGPS 1 vs.
Hartmut Bertz, Jörg Sahlmann, Donald C. McMillan, Claudia Wehr, Jesus Duque‐Afonso, Kristina Maas‐Bauer, Ralph Wäsch, Julia Nikolaychuk, Christine Greil, Jann Arends, Jürgen Finke, Robert Zeiser   +11 more
wiley   +1 more source

Marital Status and Unobserved Heterogeneity - Do twins suggest a genetic inheritance? [PDF]

The purpose of this study is to reveal the importance of unobserved heterogeneity on marital status. The results for monozygotic (identical) and dizygotic twins indicate an important genetic component in marital status.
Nilsson, William
core   +1 more source

Challenges and Pitfalls in Diagnosing Twins With Discordant BWS Phenotype

Clinical Genetics, EarlyView.
Accurately diagnosing Beckwith–Wiedemann syndrome (BWS) in twins with discordant phenotypes is essential for personalized oncological monitoring and management. It is advisable to test both twins, even without phenotypic expression, and incorporate prenatal factors like assisted reproduction technologies and twin pregnancies into the diagnostic BWS ...
Iacopo Bellani, Valentina Trevisan, Germana Viscogliosi, Maria Grazia Pomponi, Pietro Chiurazzi, Alessandro Mussa, Giuseppe Zampino, Maurizio Genuardi, Chiara Leoni   +8 more
wiley   +1 more source

Discordance in monozygotic Parkinson's disease twins – continuum or dichotomy?

Annals of Clinical and Translational Neurology, 2019
Differences in concordance rates between monozygotic and dizygotic twin pairs with Parkinson's disease (PD) have been used to estimate genetic influences in PD pathogenesis.
Alexander Balck, Max Borsche, Meike Kasten, Katja Lohmann, Philip Seibler, Norbert Brüggemann, Christine Klein   +6 more
doaj   +1 more source

DNA Methylation and Gene Expression Changes in Monozygotic Twins Discordant for Psoriasis: Identification of Epigenetically Dysregulated Genes

PLoS Genetics, 2012
Monozygotic (MZ) twins do not show complete concordance for many complex diseases; for example, discordance rates for autoimmune diseases are 20%–80%. MZ discordance indicates a role for epigenetic or environmental factors in disease.
K. Gervin, M. D. Vigeland, M. Mattingsdal, Martin Hammerø, Heidi Nygård, A. O. Olsen, Ingunn Brandt, J. Harris, D. Undlien, R. Lyle   +9 more
semanticscholar   +1 more source

Autistic traits in childhood and post‐traumatic stress disorder as young adults: a cohort study

Journal of Child Psychology and Psychiatry, EarlyView.
Background Despite the higher prevalence of childhood traumatic experiences and post‐traumatic stress disorder (PTSD) in autistic adults, research on trauma‐related psychopathology and autistic traits in young people is lacking. This study examined if high autistic traits in childhood predispose individuals to traumatic experiences, the development of ...
Alice M.G. Quinton, Freya Rumball, Angelica Ronald, Helen L. Fisher, Louise Arseneault, Francesca Happé, Andrea Danese   +6 more
wiley   +1 more source