Results 51 to 60 of about 3,744,625 (291)

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

How Monte Carlo heuristics aid to identify the physical processes of drug release kinetics

MethodsX, 2018
We implement a Monte Carlo heuristic algorithm to model drug release from a solid dosage form. We show that with Monte Carlo simulations it is possible to identify and explain the causes of the unsatisfactory predictive power of current drug release ...
Paola Lecca
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Multilevel Monte Carlo Path Simulation [PDF]

Operations Research, 2008
We show that multigrid ideas can be used to reduce the computational complexity of estimating an expected value arising from a stochastic differential equation using Monte Carlo path simulations. In the simplest case of a Lipschitz payoff and a Euler discretisation, the computational cost to achieve an accuracy of O(ϵ) is reduced from O(ϵ−3) to O(ϵ−2 (
openaire   +3 more sources

Risk of Non‐Arteritic Anterior Ischemic Optic Neuropathy in Idiopathic Intracranial Hypertension Patients Treated with GLP‐1 Receptor Agonists

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) have demonstrated significant weight‐reducing effects and may offer benefits in idiopathic intracranial hypertension (IIH); however, recent concerns about the risk of non‐arteritic anterior ischemic optic neuropathy (NAION) have emerged.
Faisal A. Al‐Harbi, Mohanad A. Alkuwaiti, Yazeed B. Alaql, Ahmed K. Alsaif, Ahmed A. Alessa, Meshari Ayed Alharbi, Mohammed Alfalah, Saud A. Alnaaim, Sajjad M. AlHaddad, Ahmed Y. Azzam   +9 more
wiley   +1 more source

Performance Analysis of Amplitude Comparison Monopulse Direction-of-Arrival Estimation

Applied Sciences, 2020
Amplitude-comparison monopulse radar in tracking radar uses the tracking scheme of a monopulse radar to estimate the angle components of a target. The performance of the amplitude comparison monopulse radar under measurement uncertainty is analysed ...
Do-Jin An, Joon-Ho Lee
doaj   +1 more source

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source

High Ener High Energy Appr gy Approximation for Monte Carlo E ximation for Monte Carlo Event gener ent generator

Eurasian Journal of Physics and Functional Materials
Analysis of the nuclear physics experiment often requires Monte Carlo simulation of the detector setup. Such kind of simulations often requires a quite advanced model of nuclear interaction.
A. N. Ismailova , Yu. L. Parfenova , P. G. Sharov, D. M. Janseitov   +3 more
doaj   +1 more source

Quasi-Monte Carlo simulation of Brownian sheet with application to option pricing

Statistical Theory and Related Fields, 2017
Monte Carlo and quasi-Monte Carlo methods are widely used in scientific studies. As quasi-Monte Carlo simulations have advantage over ordinary Monte Carlo methods, this paper proposes a new quasi-Monte Carlo method to simulate Brownian sheet via its ...
Xinyu Song, Yazhen Wang
doaj   +1 more source

PENGGUNAAN SIMULASI MONTE CARLO DALAM ESTIMASI VALUE AT RISK (VaR) PORTOFOLIO YANG DIBENTUK DARI INDEKS HARGA SAHAM MULTINASIONAL

E-Jurnal Matematika, 2022
Investment is buying an asset that is expected in the future can be resold and get a high profit value. There are two factors that must be considered when you want to invest in stocks, namely the rate of return on stocks and risk factors.
NABILA NUR JANNAH, KOMANG DHARMAWAN, LUH PUTU IDA HARINI   +2 more
doaj   +1 more source