Results 111 to 120 of about 2,855,659 (304)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

The effect of time on delay discounting in younger and older adults

open access: yesAustralian Journal of Psychology
Objective Delay discounting refers to the devaluation of future rewards as a function of time. Previous studies proposed the relationship between time perception and delay discounting in ageing, while there is a lack of evidence about the effect of ...
Lulu Liu   +3 more
doaj   +1 more source

The Modi effect: from challenger to Prime Minister [PDF]

open access: yes, 2015
Following a stimulating panel at the Jaipur Literature Festival on Southbank last month, Megha Harish reflects on “The Modi Effect” one year on from the BJP leader’s decisive victory and how traits which won him the election have persisted and are ...
Harish, Megha
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Tadalafil rehabilitation therapy preserves penile size after bilateral nerve sparing radical retropubic prostatectomy

open access: yesInternational Brazilian Journal of Urology, 2011
OBJECTIVE: To evaluate the change in penile size r bilateral nerve sparing retropubic radical prostatectomy (BNSRRP) and possible effect of Tadalafil. MATERIALS AND METHODS: A total of 65 patients underwent BNSRRP and they were evaluated prospectively ...
Ozgu Aydogdu   +4 more
doaj   +1 more source

Does the Rise in the Full Retirement Age Encourage Disability Benefits Applications? Evidence from the Health and Retirement Study [PDF]

open access: yes
As the Social Security full retirement age rises, the relative generosity of Social Security retirement benefits compared to disability benefits is declining, raising the incentive for insured people to apply for disability benefits.
Nicole Maestas, Xiaoyan Li
core  

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

Calendar Effects in Stock Markets: Critique of Previous Methodologies and Recent Evidence in European Countries [PDF]

open access: yes
This paper examines day of the week and month of the year effects in seventeen European stock market indexes in the period 1994-2007. We discuss the shortcomings of model specifications and tests used in previous work, and propose a simpler specification,
Rosa Borges
core  

Seasonal Trends in Lithuanian Stock Market [PDF]

open access: yes, 2010
Purpose of the article is to disentangle different calendar effects which leave efficiency holes in Lithuanian market. This paper presents and tests if commonly described seasonal patterns exist in Lithuanian stock market.
Simanavičienė, Žaneta   +1 more
core  

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