Results 41 to 50 of about 372,533 (293)
Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova +9 more
wiley +1 more source
Economía, Sociedad y Territorio, 2013 La comprensión del continuo regeneración urbana (ru)-calidad de vida (cdv)-calidad del lugar (cdl) en dos de las más importantes ciudades de América del Norte como medio para recuperar al centro antiguo de una decadencia social, económica y ambiental se ...
Carlos Alberto Tello-Campos +1 more
doaj
Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin +8 more
wiley +1 more source
Posterior Disconnection Syndrome in Early‐Stage Adult‐Onset Cerebral Adrenoleukodystrophy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Adult‐onset cerebral adrenoleukodystrophy is potentially treatable but often difficult to recognize before advanced cerebral involvement. Herein, we describe three men with early‐stage disease who initially presented with subtle visual complaints rather than subcortical dementia. Targeted neuropsychological testing revealed higher‐order visual
Kazuto Katsuse +13 more
wiley +1 more source
White Matter and Perivascular Imaging Changes in Alzheimer's Disease and Cerebral Amyloid Angiopathy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Peak‐width of skeletonized mean diffusivity (PSMD) and diffusion tensor imaging–analysis along the perivascular space (DTI‐ALPS), reflecting white matter integrity and glymphatic function, are altered in Alzheimer's disease (AD).
Debina Laishram +3 more
wiley +1 more source
Le multiculturalisme dans la ville : aménagement de l’espace urbain et intégration sociale
Les Ateliers de l’Ethique, 2016 Dans cet article, j’examine le rôle des villes dans l’aménagement de la diversité ethnoculturelle. Je me penche sur l’idée voulant que la prise en compte des spécificités du contexte urbain et de l’échelle géographique de la ville ait une certaine ...
Université du Québec à Montréal
doaj +1 more source
Boundary‐Dependent Sleep–Wake Dysregulation in Idiopathic Hypersomnia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Idiopathic hypersomnia (IH) presents with excessive daytime sleepiness (EDS) despite apparently preserved nocturnal sleep, challenging traditional models of hypersomnolence based on sleep loss or fragmentation. We aimed to test the hypothesis that EDS in IH reflects excessive stabilization of the sleep state, consistent with ...
Samantha Mombelli +13 more
wiley +1 more source
Ser y memoria por Pierre Levy, Universidad de Montreal
Heterotopías, 2019 El primer desafío de este artículo es reubicar el objeto de las ciencias humanas (la cultura y la significación simbólica) en continuidad con los objetos de las ciencias naturales.
Pierre Lévy
doaj
L’obsolescence des produits électroniques : des responsabilités partagées
Les Ateliers de l’Ethique, 2015 La diminution de la durée de vie des produits électroniques est à l’origine de nombreux débats. Le fabricant a traditionnellement été désigné comme le principal responsable de ce phénomène, alors que l’usager est généralement considéré comme une victime.
Université Laval +1 more
doaj +1 more source
Subjective Cognitive Concerns and Cognitive Trajectories in Parkinson's Disease: Biomarker Impact
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To examine the relationship of subjective cognitive concerns (SCC) with biomarkers of Alzheimer's disease (AD), neurodegeneration, and Parkinson's disease (PD) and domain‐specific cognitive trajectories among cognitively unimpaired persons with de novo PD. Method Cognitively unimpaired participants with SCC (n = 294) and without SCC (
Francesca V. Lopez +5 more
wiley +1 more source